(A) Serotype distribution of the viable Streptococcus pneumoniae isolates causing invasive disease in patients of all ages, South Africa, 2010-2012 (n = 7,442). Other refers to the remaining serotypes detected by the Quellung reaction. (B) Serotype distribution of the nonviable isolates (n = 704) and culture-negative clinical specimens (n = 138) of Streptococcus pneumoniae (lytA CT value of <35) causing invasive disease in patients of all ages, South Africa, 2010-2012. Other refers to the remaining serotypes included in the PCR assay, and NEG42 refers to the samples negative for the 42 serotypes detected by the assay.