TABLE 2.
MLST and amino acid substitutions in PBPs among serotype Ib GBS clinical isolates
| Categorya and isolate no. | MLST sequence type | Amino acid substitution inb: |
||||||
|---|---|---|---|---|---|---|---|---|
| PBP 2X | PBP 2B | PBP 1A | ||||||
| PRGBS | ||||||||
| A1 | 1 | —c | A400V | V405A | — | Q557E | T567I | — |
| A2 | 1 | — | A400V | V405A | — | Q557E | T567I | — |
| CTBr PSGBS | ||||||||
| B1 | 1 | T394A | — | — | G429S | — | T567I | — |
| B2 | 1 | T394A | — | — | — | — | T567I | T145A |
| B3 | 1 | T394A | — | — | G429S | — | T567I | — |
| B4 | 1 | T394A | — | — | — | — | T567I | T145A |
| B5 | 1 | T394A | — | — | G429S | — | T567I | — |
| B6 | 1 | T394A | — | — | — | — | T567I | T145A |
| PSGBS | ||||||||
| B7 | 10 | — | — | — | — | — | — | — |
a
PRGBS, GBS isolates with reduced penicillin susceptibility; CTBr PSGBS, PSGBS with no growth inhibition zones around a ceftibuten disk; PSGBS, penicillin-susceptible GBS.
b
Amino acid substitutions compared to the sequences of Streptococcus agalactiae strains 2603V/R and NEM316.
c
—, no substitution was observed on the basis of the amino acid sequences of the reference strains described above.