TABLE 1.
Scrapie isolates tested in mixes with BSE
| Scrapie typea | Genotypeb | No. of isolatesc | No. of BSE isolate spikesd | No. of analysese |
|---|---|---|---|---|
| Classical | ARQ/ARQ | 4 | 6 | 8 |
| VRQ/VRQ | 6 | 6 | 12 | |
| ARQ/VRQ | 6 | 6 | 12 | |
| AHQ/AHQ | 2 | 4 | 4 | |
| AHQ/ARQ | 4 | 6 | 8 | |
| AHQ/VRQ | 3 | 5 | 6 | |
| ARH/ARH | 4 | 6 | 8 | |
| ARH/ARQ | 4 | 6 | 8 | |
| ARH/VRQ | 4 | 6 | 8 | |
| ARR/VRQ | 4 | 6 | 8 | |
| Atypical | AHQ/ARQ | 4 | 6 | 8 |
| ARR/ARR | 1 | 2 | 2 | |
| ARQ/ARQ | 1 | 2 | 2 | |
| CH1641 | AHQ/ARQ | 3 | 5 | 6 |
| Caprine scrapie | ARQ/ARQ | 4 | 2 | 8 |
| Total | 54 | 108 |
Scrapie isolates that were used in this study are listed as either classical, atypical, or CH1641 (all ovine) or caprine scrapie.
PRNP genotype of the scrapie isolate at codon positions 136, 154, and 171.
The number of scrapie isolates of each individual genotype.
The number of independent isolates of either ovine or caprine BSE that were spiked into scrapie samples of that particular genotype. Each scrapie isolate was spiked with 2 distinct BSE samples. In total, 6 ovine BSE isolates were used (4 of the ARQ/ARQ genotype, 2 of the AHQ/AHQ genotype), and 2 caprine BSE isolates were used (ARQ/ARQ genotype).
The number of individual sample mixes for each genotype that were prepared and analyzed. Total number of BSE/scrapie mixes analyzed was 108; in addition, 108 samples consisting of just the scrapie samples alone were tested.