TABLE 2.
Sensitivities, specificities, and predictive values of the CAP/CTM with DBS or DPS for diagnosing ARV TFa,b
| Specimen type | No. of plasma DBS or DPS pairs | Diagnostic threshold, copies/ml | Sensitivity (CI) | Specificity (CI) | PPV (CI) | NPV (CI) |
|---|---|---|---|---|---|---|
| DBS | 823 | >5,000 | 0.99 (0.96–1.00) | 0.55 (0.51–0.59) | 0.33 (0.29–0.37) | 1.00 (0.98–1.00) |
| >1,000 | 0.99 (0.97–1.00) | 0.26 (0.22–0.29) | 0.29 (0.26–0.33) | 0.99 (0.96–1.00) | ||
| DPS | 546 | >5,000 | 0.88 (0.81–0.94) | 0.98 (0.96–0.99) | 0.92 (0.85–0.97) | 0.97 (0.95–0.98) |
| >1,000 | 0.91 (0.85–0.95) | 0.96 (0.94–0.98) | 0.89 (0.83–0.94) | 0.97 (0.94–0.98) |
a
Plasma VL is the reference standard for sensitivity, specificity, and predictive values of VL in DBS or DPS. Plasma, DBS, or DPS that had a VL that was undetectable or lower than the LOD were classified as negative (i.e., <5,000 copies/ml or <1,000 copies/ml) for ARV TF.
b
All confidence intervals (CIs) are reported at the 95% confidence level.