TABLE 3.
Performance of rapid antimicrobial susceptibility testing of Gram-positive cocci (n = 68)
Antimicrobial agent (n) | No. of isolate-antibiotic combinations | No. of isolates that werea: |
No. (%) of errors |
Categorical agreement (%) | Essential agreement (%) | |||
---|---|---|---|---|---|---|---|---|
Resistant | Susceptible | Very major | Major | Minor | ||||
Staphylococcus spp. (48) | 872 | 275 | 586 | 4 (1.5) | 2 (0.3) | 0 | 99.3 | 99.0 |
Penicillin G | 48 | 42 | 6 | 100 | 100 | |||
Oxacillin | 48 | 30 | 18 | 100 | 97.9 | |||
Clindamycin | 48 | 22 | 26 | 100 | 100 | |||
Erythromycin | 48 | 30 | 18 | 100 | 100 | |||
Levofloxacin | 48 | 25 | 23 | 100 | 100 | |||
Moxifloxacin | 48 | 15 | 23 | 100 | 100 | |||
Gentamicin | 48 | 19 | 29 | 100 | 100 | |||
Tobramycin | 48 | 23 | 25 | 100 | 100 | |||
Vancomycin | 48 | 0 | 48 | 100 | 100 | |||
Teicoplanin | 48 | 7 | 41 | 2 | 1 | 93.8 | 89.6 | |
Linezolid | 48 | 0 | 48 | 100 | 97.9 | |||
Tetracycline | 48 | 18 | 29 | 1 | 97.9 | 97.9 | ||
Tigecycline | 48 | 0 | 48 | 100 | 100 | |||
Trimethoprim-sulfamethoxazole | 48 | 17 | 31 | 100 | 100 | |||
Fusidic acid | 48 | 9 | 39 | 1 | 1 | 95.8 | 97.9 | |
Fosfomycin | 48 | 14 | 34 | 100 | 100 | |||
Rifampin | 48 | 4 | 44 | 100 | 100 | |||
Nitrofurantoin | 48 | 0 | 48 | 100 | 100 | |||
Mupirocin | 8 | 0 | 8 | 100 | 100 | |||
Enterococcus spp. (17) | 238 | 91 | 144 | 1 (1.1) | 0 | 1 (0.4) | 99.2 | 98.7 |
Penicillin G | 17 | 13 | 4 | 100 | 94.1 | |||
Ampicillin | 17 | 10 | 7 | 100 | 100 | |||
Ampicillin-sulbactam | 17 | 13 | 4 | 100 | 100 | |||
Imipenem | 17 | 10 | 7 | 100 | 100 | |||
Erythromycin | 17 | 14 | 0 | 1 | 94.1 | 94.1 | ||
Levofloxacin | 17 | 10 | 7 | 100 | 100 | |||
Vancomycin | 17 | 1 | 16 | 100 | 100 | |||
Teicoplanin | 17 | 1 | 16 | 100 | 100 | |||
Linezolid | 17 | 1 | 16 | 100 | 100 | |||
Tetracycline | 17 | 8 | 9 | 100 | 100 | |||
Tigecycline | 17 | 0 | 17 | 100 | 100 | |||
Trimethoprim-sulfamethoxazole | 17 | 0 | 17 | 100 | 100 | |||
Quinupristin-dalfopristin | 17 | 6 | 11 | 100 | 100 | |||
Nitrofurantoin | 17 | 4 | 13 | 1 | 94.1 | 100 | ||
Total Gram-positive cocci (68) | 1,163 | 377 | 767 | 6 (1.6)b,c | 2 (0.3)b | 1 (0.1)b | 99.2b | 99.1b,c |
The number of results within the intermediate category can be calculated by subtracting the resistant and susceptible results from the number of isolate-antibiotic combinations tested.
Streptococci (S. pneumoniae, n = 2 and S. agalactiae, n = 1) are included in the total number of Gram-positive cocci and in the calculation of the error and agreement rates for all Gram-positive cocci. No separate calculation of error and agreement rates was performed for streptococci because of the small number of isolates.
One VME (tetracycline in a S. pneumoniae isolate) and no other errors were observed in streptococci. Essential agreement (EA) was observed for all streptococcal isolate-antibiotic combinations.