TABLE 1.
MICs of K. pneumoniae and E. coli isolates, their transformants, and control strains
| Drug | MIC (μg/ml) |
||||||
|---|---|---|---|---|---|---|---|
| K. pneumoniae KP2 |
E. coli TOP10 transformants for KP2 |
E. coli EC2 | E. coli TOP10 transformant for EC2 (pNDM-7-EC2) | E. coli TOP10 | |||
| pCTX-M-15 | pNDM-7-KP2 | pRmtF | |||||
| Imipenem | >8 | ≤1 | 2 | ≤1 | >8 | 2 | ≤1 |
| Ertapenem | >4 | ≤0.25 | 4 | ≤0.25 | 4 | 4 | ≤0.25 |
| Doripenem | >2 | ≤0.12 | >2 | ≤0.12 | >2 | >2 | ≤0.12 |
| Meropenem | >8 | ≤1 | 4 | ≤1 | 2 | 4 | ≤1 |
| Ceftazidime | >16 | >16 | >16 | ≤1 | >16 | >16 | ≤1 |
| Cefotaxime | >32 | >32 | >32 | ≤1 | >32 | >32 | ≤1 |
| Ticarcillin-clavulanate | >128/2 | 128/2 | >128/2 | ≤16/2 | >128/2 | >128/2 | ≤16/2 |
| Piperacillin-tazobactam | >64/4 | ≤8/4 | >64/4 | ≤8/4 | >64/4 | >64/4 | ≤8/4 |
| Cefepime | >16 | >16 | 16 | ≤2 | >16 | 16 | ≤2 |
| Aztreonam | >16 | >16 | ≤2 | ≤2 | 16 | ≤2 | ≤2 |
| Gentamicin | >8 | ≤1 | ≤1 | >8 | >8 | ≤1 | ≤1 |
| Tobramycin | >8 | ≤1 | ≤1 | >8 | 8 | ≤1 | ≤1 |
| Amikacin | >32 | 8 | ≤4 | >32 | ≤4 | ≤4 | ≤4 |
| Ciprofloxacin | >2 | ≤0.25 | ≤0.25 | ≤0.25 | >2 | ≤0.25 | ≤0.25 |
| Levofloxacin | 8 | ≤1 | ≤1 | ≤1 | >8 | ≤1 | ≤1 |
| Doxycycline | 8 | ≤2 | ≤2 | ≤2 | >8 | ≤2 | ≤2 |
| Minocycline | 16 | ≤2 | ≤2 | ≤2 | 8 | ≤2 | ≤2 |
| Tigecycline | 1 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 |
| Trimethoprim-sulfamethoxazole | >4/76 | >4/76 | ≤/0.5/9.5 | ≤0.5/9.5 | >4/76 | ≤0.5/9.5 | ≤0.5/9.5 |
| Colistin | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 |
| Polymyxin B | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 | ≤0.25 |