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CCoV-I and CCoV-II spike genes with the location of the N-terminal domain (NTD), S1 receptor binding domain, S1/S2 cleavage site (S1/S2), S2′ cleavage site (S2′), S2 fusion domain, and transmembrane domain (TM). Note that the S1/S2 furin cleavage site is present only in CCoV-I viruses.
