FIG 2.

Photomicrographs of small intestine from puppy 8 with typical lesions of CCoV infection. (A) The villus epithelial cells are diffusely disorganized, attenuated, and low cuboidal (arrows). Note that the space between the epithelial cells and the lamina propria is an artifact of processing (hematoxylin and eosin stain; bar, 100 μm). (B) Cross-section of small intestine showing CCoV antigen in villus epithelial cells (arrows; immunohistochemical stain; bar, 500 μm). (C) Higher magnification showing CCoV antigen in the cytoplasm of villus epithelial cells (arrows; immunohistochemical stain; bar, 50 μm).