TABLE 4.
Results of CCoV genotyping and subtyping with S2′ and S1/S2 cleavage site sequences
| CCoVa (case) | Genotype | Subtypec | Cleavage site sequenceb |
|
|---|---|---|---|---|
| S2′ | S1/S2 | |||
| 89334-09 (2) | II | ND | KRKYRS | ARTR—–G |
| 97736-09 (3) | II | a | KRKYRS | ERTR—–G |
| 107207 (4a) | II | ND | KRKYRS | DRTR—–G |
| 110089-09 (4b) | II | a | KRKYRS | ARTR—–G |
| 123567-09 (5) | II | a | KRKYRS | ERTR—–G |
| 51534-10A (6a) | II | ND | KRKYRS | ARTR—–G |
| 120628-12 (7) | II | a | KRKYRS | ND |
| 159396-12 (8) | II | a | KRKYRS | ERTR—–G |
| 47387-13 (9) | II | b | KRKYRS | ARTR—–G |
| Reference | ||||
| CB/05 | II | a | KRKYRS | ARTR—–G |
| 1-71 | II | a | KRKYRS | ERTR—–G |
| 341/05 | II | b | KRKYRS | ARTR—–G |
| Elmo/02 | I | NA | QPGGRS | VRRARRAVQG |
a
The reference CCoVs are the following: CB/05, pantropic CCoV-IIa (AAZ91437.1); 1-71, enteric CCoV-IIa (AAV65515.1); 341/05, CCoV-IIb (ACJ63231.1); and Elmo/02, CCoV-I (AAP72149). They are included to highlight the conserved nature of the S2′ cleavage site within genotype II viruses.
b
Basic residues suspected to be important for cleavage activation of the spike protein are in boldface.
c
ND, not determined. NA, not applicable.