Table 3.
Comparison of Drug Resistance Effects Between Reported Mutations Selected in This Study and Those in the HIV Drug Resistance Database of Stanford University
| Level of resistance (increased folds of EC50) | |||
|---|---|---|---|
| Drug | Mutations | In this study | In HIV drug resistance database |
| NVP | V90I | M (4) | L (UD) |
| K101E | M (12) | M (9) | |
| V106I | M (11) | No effect | |
| V106M | H (21) | H (70) | |
| V108I | L (3) | L (UD) | |
| F116L | L (1) | Unknown | |
| E138G | M (6) | No effect | |
| E138R | H (55) | Unknown | |
| Y181C | H (105) | H (123) | |
| Y188C | H (61) | H (216) | |
| G190A | H (69) | H (91) | |
| H221Y | M-H | No effect | |
| EFV | L100I | H (53) | M (10) |
| V106L | H (76) | No effect | |
| F116Y | M (12) | No effect | |
| Y188C | H (51) | L-H (352) | |
| 3TC | D67N | L (3) | Unknown |
| V90I | L (2) | Unknown | |
| M184I | H (1543) | H (200) | |
H, high level of resistance [fold change (FC)>20]; M, medium level of resistance (20>FC>4); L, low level of resistance (FC<4). UD, undetected. They were defined according to the Stanford database http://hivdb.stanford.edu/cgi-bin/Marvel.cgi