Table 2.
MTHFR C677T and RFC-1 Polymorphism Susceptibility Risks in Patients with Neuroblastoma, Their Mothers, and the Combination of Genotypes
| Neuroblastoma | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Child | Mother | Combineda | ||||||||||
| Polymorphism | Genotypes | n (%) | OR (95% CI) | p | Controls, n (%) | Case, n (%) | OR (95% CI) | p | Controls, n | Case, n | OR (95% CI) | p |
| MTHFR (C677T) | ||||||||||||
| rs1801133 | CC | 36 (54.5) | 1 (ref) | 37 (49.3) | 17 (55.0) | 1 (ref) | 4 | 14 | 1 (ref) | |||
| CT | 24 (36.4) | 1.05 (0.59–1.88) | 0.87 | 32 (42.7) | 11 (35.0) | 0.75 (0.31–1.83) | 0.52 | — | — | — | — | |
| CT+CT | — | — | — | — | — | — | — | 4 | 6 | 0.43 (0.08–2.31) | 0.32 | |
| TT | 6 (9.1) | 1.27 (0.47–3.43) | 0.64 | 6 (8.0) | 3 (10.0) | 1.09 (0.24–4.88) | 0.91 | — | — | — | — | |
| TT+TT | — | — | — | — | — | — | — | 0 | 2 | — | — | |
| CT/TTb | 30 (45.5) | 1.09 (0.63–1.88) | 0.76 | 38 (50.7) | 14 (45.0) | 0.80 (0.35–1.86) | 0.61 | — | — | — | — | |
| CT/TT+CT/TT | — | — | — | — | — | — | — | 6 | 10 | 0.48 (0.11–2.14) | 0.33 | |
| RFC-1 (G80A) | ||||||||||||
| rs1051266 | GG | 11 (17.2) | 1 (ref) | 30 (35.7) | 5 (15.2) | 1 (ref) | 7 | 3 | 1 (ref) | |||
| GG+GA | — | — | — | — | — | — | — | 4 | 1 | 0.58 (0.04–7.66) | 0.68 | |
| GA+GG | — | — | — | — | — | — | — | 3 | 2 | 1.56 (0.16–14.65) | 0.70 | |
| GA | 33 (51.6) | 2.21 (1.05–4.66) | 0.04 | 35 (41.7) | 18 (54.5) | 3.09 (1.02–9.31) | 0.05 | — | — | — | — | |
| GA+GA | — | — | — | — | — | — | — | 5 | 10 | 4.67 (0.83–26.24) | 0.08 | |
| AA | 20 (31.2) | 3.21 (1.41–7.33) | <0.01 | 19 (22.6) | 10 (30.3) | 3.16 (0.93–10.67) | 0.06 | — | — | — | — | |
| GA+AA | — | — | — | — | — | — | — | 1 | 3 | 7.00 (0.50–97.75) | 0.15 | |
| AA+GA | — | — | — | — | — | — | — | 0 | 5 | 0 | 0 | |
| AA+AA | — | — | — | — | — | — | — | 2 | 7 | 8.17 (1.03–64.94) | 0.05 | |
| GA/AAb | 53 (82.8) | 2.51 (1.24–5.08) | 0.01 | 54 (64.3) | 28 (84.8) | 3.11 (1.09–8.90) | 0.03 | — | — | — | — | |
| GA/AA+GA/AA | — | — | — | — | — | — | — | 8 | 25 | 7.29 (1.52–35.03) | 0.01 | |
a
Combination of child–mother genotypes.
b
CT/TT, GA/AA indicates at least one variant allele.