Table 3.
MTHFR C677T and RFC-1 Polymorphism Susceptibility Risks in Patients with Nephroblastoma, Their Mothers, and the Combination of Genotypes
| Nephroblastoma | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Child | Mother | Combineda | ||||||||||
| Polymorphism | Genotypes | n (%) | OR (95% CI) | p | Controls, n (%) | Case, n (%) | OR (95% CI) | p | Controls, n | Case, n | OR (95% CI) | p |
| MTHFR (C677T) | ||||||||||||
| rs1801133 | ||||||||||||
| CC | 43 (53.7) | 1 (ref) | 37 (49.3) | 24 (50.0) | 1 (ref) | 4 | 18 | 1 (ref) | ||||
| CT | 30 (37.5) | 1.09 (0.64–1.88) | 0.73 | 32 (42.7) | 21 (43.7) | 1.01 (0.48–2.15) | 0.98 | — | — | — | — | |
| CT+CT | — | — | — | — | — | — | — | 4 | 11 | 0.61 (0.13–2.95) | 0.54 | |
| TT | 7 (8.8) | 1.24 (0.48–3.16) | 0.65 | 6 (8.0) | 3 (6.3) | 0.77 (0.18–3.38) | 0.73 | — | — | — | — | |
| TT+TT | — | — | — | — | — | — | — | 0 | 0 | 0 | 0 | |
| CT/TTb | 37 (46.3) | 1.12 (0.68–1.86) | 0.65 | 38 (50.7) | 24 (50.0) | 0.97 (0.47–2.01) | 0.94 | — | — | — | — | |
| CT/TT+CT/TT | — | — | — | — | — | — | — | 6 | 18 | 0.67 (0.16–2.77) | 0.58 | |
| RFC-1 (G80A) | ||||||||||||
| rs1051266 | GG | 13 (17.0) | 1 (ref) | 30 (35.7) | 15 (28.3) | 1 (ref) | 7 | 6 | 1 (ref) | |||
| GG+GA | — | — | — | — | — | — | — | 4 | 5 | 1.46 (0.26–8.05) | 0.66 | |
| GA+GG | — | — | — | — | — | — | — | 3 | 9 | 3.50 (0.64–19.19) | 0.15 | |
| GA | 38 (49.3) | 2.16 (1.07–4.33) | 0.03 | 35 (41.7) | 26 (49.0) | 1.49 (0.67–3.31) | 0.33 | — | — | — | — | |
| GA+GA | — | — | — | — | — | — | — | 5 | 11 | 2.57 (0.56–11.72) | 0.22 | |
| AA | 26 (33.7) | 3.53 (1.65–7.59) | <0.01 | 19 (22.6) | 12 (22.7) | 1.26 (0.49–3.27) | 0.63 | — | — | — | — | |
| GA+AA | — | — | — | — | — | — | — | 1 | 4 | 4.67 (0.40–53.95) | 0.22 | |
| AA+GA | — | — | — | — | — | — | — | 0 | 9 | 0 | 0 | |
| AA+AA | — | — | — | — | — | — | — | 2 | 7 | 4.08 (0.60–27.65) | 0.15 | |
| GA/AAb | 64 (83.0) | 2.56 (1.33–4.95) | <0.01 | 54 (64.3) | 38 (71.7) | 1.41 (0.67–2.97) | 0.37 | — | — | — | — | |
| GA/AA+GA/AA | — | — | — | — | — | — | — | 8 | 31 | 4.52 (1.18–17.25) | 0.03 | |
a
Combination of child–mother genotypes.
b
CT/TT, GA/AA indicates at least one variant allele.