Table 2.

Unadjusted Simple Linear Regression Values of Associations with High-Density Lipoprotein Cholesterol Efflux Capacity

	Standardized beta coefficient	p-value
Lipid panel
Total cholesterol, mg/dl	0.259	0.005
LDL-C, mg/dl	0.086	0.353
HDL-C, mg/dl	0.395	<0.001
Triglycerides, mg/dl	0.065	0.487
Cholesterol ratio (total/HDL-C)	−0.184	0.046
TG/HDL-C ratio	−0.042	0.655
Apo-AI, ng/ml	−0.121	0.194
Apo-AII, ng/ml	−0.148	0.110
Apo-B, ng/ml	−0.170	0.066
Apo-CII, ng/ml	−0.104	0.262
Apo-CIII, ng/ml	−0.136	0.143
Apo-E, ng/ml	−0.118	0.204
Baseline demographics
Age, years	0.003	0.975
Waist size, cm	−0.136	0.142
Weight, kg	−0.228	0.013
Height, cm	−0.164	0.077
BMI, kg/m2	−0.164	0.075
CRP, μg/ml	−0.061	0.510
CD4+ T cell count, cells/mm3	−0.032	0.730
FRS score	−0.184	0.046
FRS class	−0.186	0.044
Lipid-lowering medications	0.077	0.406
Metabolic assessment
Fasting glucose, mg/dl	−0.208	0.024
Fasting insulin, mg/dl	−0.139	0.134
Matsuda indexa	0.218	0.029
NMR spectroscopy
VLDL particle (VLDL-P) conc., nmol/liter
Total VLDL-P	0.127	0.170
Large VLDL-P	0.021	0.820
Medium VLDL-P	0.172	0.063
Small VLDL-P	0.029	0.756
LDL particle (LDL-P) conc., nmol/liter
Total LDL-P	−0.052	0.579
Large LDL-P	0.165	0.074
Small LDL-P	−0.198	0.031
HDL particle (HDL-P) conc., μmol/liter
Total HDL-P	0.399	<0.001
Large HDL-P	0.337	<0.001
Medium HDL-P	0.400	<0.001
Small HDL-P	−0.129	0.164
IDL Particle conc., nmol/liter
Total IDL-P	0.189	0.041
Mean particle size, nm
VLDL	0.003	0.971
LDL	0.174	0.059
HDL	0.253	0.006

^aN=101.

p-value<0.05.

The standardized beta coefficient is based on a one standard deviation of change in the exposure on the outcome and provides context to each variable's contribution to HDL efflux variance.

conc., concentration; CRP, C-reactive protein; LDL, low-density lipoprotein; HDL, high-density lipoprotein; VLDL, very-low-density lipoprotein; IDL, intermediate-density lipoprotein; TG, triglycerides; Apo, apolipoprotein; FRS, Framingham Risk Score.