Table 2.
Unadjusted and adjusted regression coefficients (β) of log 10 transformed cytokine levels with CIS20r fatigue score as outcome.
| Unadjusted β (se) |
Adjusted β (se) |
P value β adj |
Explained variance R 2 |
Adjustment for confounding by | |
|---|---|---|---|---|---|
| Pro-inflammatory cytokines | |||||
| IL-1β | −2.250 (7.777) | −16.407 (10.719) | 0.138 | 0.163 | Age, type of MS, duration of MS, EDSS, DMDs |
| IL-2 | −1.345 (6.008) | −2.676 (6.996) | 0.705 | 0.019 | Type of MS, EDSS, DMDs |
| IL-6 | 14.551 (6.748)* | 19.642 (7.036)* | 0.009 | 0.211 | Age |
| IL-8 | 17.396 (11.875) | 17.396 (11.875) | 0.152 | 0.061 | — |
| IL-12p70 | 1.074 (4.012) | −2.292 (5.383) | 0.674 | 0.070 | Age, type of MS, EDSS, DMDs |
| IL-17 | 8.067 (6.003) | 9.011 (6.282) | 0.161 | 0.064 | EDSS |
| TNF-α | 6.656 (18.071) | 4.950 (18.824) | 0.794 | 0.005 | Duration of MS |
| IFN-γ | 3.294 (5.806) | 3.749 (6.261) | 0.554 | 0.061 | Age, type of MS, DMDs |
| Anti-inflammatory cytokines | |||||
| IL-4 | −11.081 (11.980) | −20.440 (15.070) | 0.186 | 0.106 | Age, duration of MS, EDSS |
| IL-5 | −1.479 (4.556) | −4.594 (5.673) | 0.425 | 0.092 | Age, gender, type of MS, duration of MS, DMDs |
| IL-10 | −2.225 (4.655) | −6.806 (5.995) | 0.267 | 0.136 | Age, gender, type of MS, duration of MS, EDSS, DMDs |
| IL-13 | −2.804 (5.097) | −7.884 (6.467) | 0.233 | 0.113 | Age, type of MS, EDSS, DMDs |
*Significant β.