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. Author manuscript; available in PMC: 2015 Feb 2.
Published in final edited form as: Annu Rev Genet. 2009;43:197–222. doi: 10.1146/annurev-genet-102108-134304

Figure 5.

Figure 5

Figure 5

The V. cholerae quorum-sensing circuit. (A) Signal transduction at LCD. During this stage, autoinducer levels are low and the CqsS and LuxPQ receptors function as kinases. LuxO is phosphorylated, the Qrr1-4 sRNAs are transcribed, and HapR protein is not produced. (B) Signal transduction at HCD. During this stage, autoinducer levels are high and the CqsS and LuxPQ receptors function as phosphatases. LuxO is unphosphorylated, Qrr1-4 sRNAs are not transcribed, and HapR protein is produced. Solid and dotted lines denote regulatory factors that are produced and not produced, respectively. Refer to text for details.