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. Author manuscript; available in PMC: 2015 Feb 2.
Published in final edited form as: Science. 2010 Mar 11;328(5976):327–334. doi: 10.1126/science.1182374

Fig. 4.

Fig. 4

Requirement of DCR-1 cleavage by CED-3 for its pro-apoptotic activity. Cell corpses were scored in the following animals: (A) N2, dcr-1(ok247), dcr-1(ok247); ex[Pdcr-1DCR-1] arrays #1–3, (B) N2, dcr-1(ok247), dcr-1(ok247); ex[Pdcr-1DCR-1(D1472E)] arrays #1–3, (C) N2, dcr-1(ok247), dcr-1(ok247); ex[Pdcr-1tDCR-1] arrays #1–3, (D) N2, dcr-1(ok247), dcr-1(ok247); ex[Pdcr-1DCR-1(E1E2)] arrays #1–3, (E) N2, dcr-1(ok247), dcr-1(ok247); ex[Pdcr-1DCR-1(E1D1E2)] arrays #1–3, (F) ced-1(e1735), ced-1(e1735); ex[PhsptDCR-1] arrays #1–3, (G) ced-1(e1735), ced-1(e1735); ex[PhsptDCR-1(del)] arrays #1–3. Stages of embryos examined were: comma, 1.5-fold, 2-fold, 2.5-fold, 3-fold, and 4-fold. The y axis represents average number of cell corpses scored and error bars represent S.D. 15 embryos were counted for each developmental stage. The significance of differences between different genetic backgrounds was determined by two-way ANOVA, followed by Bonferroni comparison. *, P < 0.001; **, P < 0.05. All other points had P values > 0.05.