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. Author manuscript; available in PMC: 2015 Feb 2.
Published in final edited form as: Kidney Int. 2009 Aug 5;76(8):831–837. doi: 10.1038/ki.2009.284

Figure 2. The Role of COMT)/2-methoxyestradiol (2-ME in Pregnancy.

Figure 2

In normal pregnancy, 2-ME may play a role in regulating hypoxia-inducible factor (HIF)-1α in diverse ways. In preeclampsia, low COMT/2-ME may induce accumulation of HIF-1α, vascular defect, placental hypoxia and inflammatory responses in the placenta. Such response may induce placental defects and result in suppression of placental-derived estradiol and further reduction in 2-ME levels. CYP450, cytochrome 450.