Table 6.
Comparison of the size of hippocampal subfields and parahippocampal gyrus subregions between aMCI patients and controls, with age and ICV as covariates
| ASHS | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Volume | Normalized volume | ||||||||||
| CA1 | CA2 | CA3 | CA | DG | SUB | HIPP | ERC | BA35 | BA36 | PRC | |
| Left side | |||||||||||
| Mean (NC) | 1241.80 | 14.86 | 62.30 | 1318.96 | 760.79 | 343.22 | 2422.97 | 25.04 | 19.82 | 80.75 | 100.47 |
| Mean (MCI) | 1089.93 | 13.81 | 56.68 | 1160.42 | 675.28 | 323.43 | 2159.12 | 22.84 | 16.16 | 71.01 | 87.13 |
| SD (NC) | 115.40 | 5.58 | 18.03 | 118.15 | 86.89 | 46.07 | 204.26 | 2.66 | 3.33 | 15.03 | 16.23 |
| SD (MCI) | 193.09 | 5.90 | 17.47 | 196.97 | 126.67 | 55.19 | 349.46 | 5.00 | 3.56 | 14.14 | 15.82 |
| T‐stat | 4.35 | 0.83 | 1.43 | 4.45 | 3.58 | 1.76 | 4.20 | 2.51 | 4.80 | 3.01 | 3.76 |
| P‐value | 4.0 e− 05 | 0.41 | 0.16 | 2.8 e− 05 | 0.00060 | 0.082 | 6.9 e− 05 | 0.014 | 7.3 e− 06 | 0.0035 | 0.00033 |
| AUC | 0.783 | 0.572 | 0.581 | 0.785 | 0.730 | 0.615 | 0.763 | 0.668 | 0.784 | 0.685 | 0.727 |
| AUC 95% C.I. radius | 0.102 | 0.126 | 0.125 | 0.101 | 0.111 | 0.123 | 0.108 | 0.121 | 0.102 | 0.116 | 0.109 |
| Right side | |||||||||||
| Mean (NC) | 1258.97 | 21.29 | 72.43 | 1352.68 | 760.47 | 341.84 | 2455.00 | 24.26 | 19.42 | 69.38 | 88.74 |
| Mean (MCI) | 1117.07 | 18.27 | 64.17 | 1199.51 | 691.88 | 319.05 | 2210.44 | 22.95 | 17.94 | 69.66 | 87.51 |
| SD (NC) | 134.38 | 5.22 | 20.86 | 138.93 | 95.85 | 45.81 | 240.49 | 3.93 | 4.09 | 14.47 | 16.74 |
| SD (MCI) | 187.65 | 5.01 | 23.12 | 197.77 | 122.89 | 58.81 | 357.78 | 5.19 | 4.35 | 15.29 | 17.87 |
| T‐stat | 3.95 | 2.66 | 1.70 | 4.07 | 2.82 | 1.96 | 3.65 | 1.29 | 1.58 | −0.09 | 0.32 |
| P‐value | 0.00017 | 0.0094 | 0.094 | 0.00011 | 0.0060 | 0.054 | 0.00047 | 0.20 | 0.12 | 0.93 | 0.75 |
| AUC | 0.726 | 0.645 | 0.605 | 0.736 | 0.667 | 0.615 | 0.709 | 0.585 | 0.622 | 0.478 | 0.504 |
| AUC 95% C.I. radius | 0.110 | 0.119 | 0.126 | 0.108 | 0.117 | 0.123 | 0.112 | 0.126 | 0.124 | 0.127 | 0.127 |
| FreeSurfer | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PreSub | CA1 | CA23 | Fimb | Sub | DG | H. Fissure | H. Other | HIPP (FS) | ERC (FS) | |
| Left side | ||||||||||
| Mean (NC) | 423.54 | 303.80 | 870.93 | 59.50 | 575.99 | 488.49 | 40.47 | 320.14 | 3727.28 | 1983.02 |
| Mean (MCI) | 382.88 | 300.66 | 800.24 | 47.14 | 518.65 | 445.27 | 45.21 | 306.60 | 3311.30 | 1747.60 |
| SD (NC) | 56.42 | 38.52 | 96.95 | 24.62 | 61.98 | 56.24 | 16.20 | 60.79 | 331.64 | 360.22 |
| SD (MCI) | 68.70 | 41.25 | 117.88 | 23.60 | 87.86 | 69.82 | 27.43 | 68.27 | 573.46 | 393.33 |
| T‐stat | 2.93 | 0.36 | 2.97 | 2.31 | 3.43 | 3.09 | −0.96 | 0.95 | 4.05 | 2.82 |
| P‐value | 0.0044 | 0.72 | 0.0040 | 0.023 | 0.0010 | 0.0028 | 0.34 | 0.35 | 0.00012 | 0.0060 |
| AUC | 0.660 | 0.542 | 0.678 | 0.633 | 0.706 | 0.688 | 0.492 | 0.638 | 0.744 | 0.688 |
| AUC 95% C.I. radius | 0.119 | 0.128 | 0.117 | 0.121 | 0.116 | 0.117 | 0.130 | 0.125 | 0.110 | 0.119 |
| Right side | ||||||||||
| Mean (NC) | 406.80 | 314.29 | 928.21 | 34.41 | 561.43 | 517.39 | 46.01 | 340.73 | 3710.02 | 1768.22 |
| Mean (MCI) | 390.77 | 304.59 | 844.73 | 28.73 | 527.25 | 473.94 | 47.65 | 325.60 | 3382.20 | 1698.44 |
| SD (NC) | 51.90 | 38.72 | 108.96 | 16.27 | 55.40 | 64.23 | 20.03 | 51.95 | 430.72 | 357.83 |
| SD (MCI) | 72.09 | 41.89 | 120.13 | 18.03 | 84.00 | 70.80 | 21.28 | 58.56 | 531.40 | 436.49 |
| T‐stat | 1.16 | 1.09 | 3.29 | 1.49 | 2.18 | 2.91 | −0.36 | 1.24 | 3.07 | 0.79 |
| P‐value | 0.25 | 0.28 | 0.0015 | 0.14 | 0.032 | 0.0047 | 0.72 | 0.22 | 0.0029 | 0.43 |
| AUC | 0.566 | 0.576 | 0.706 | 0.598 | 0.642 | 0.683 | 0.485 | 0.595 | 0.693 | 0.526 |
| AUC 95% C.I. radius | 0.127 | 0.125 | 0.113 | 0.124 | 0.126 | 0.116 | 0.129 | 0.125 | 0.116 | 0.128 |
The top panel of the figure lists summary statistics and group difference statistics for the different anatomical labels generated by ASHS, and the bottom panel lists corresponding statistics for the different FreeSurfer labels, which include substructures segmented by the Van Leemput et al. [2009] algorithm, as well as the whole hippocampus volume and ERC gray matter volume. For ASHS hippocampal subfield labels and all FreeSurfer labels, the statistics are computed on volume measurements. For ASHS parahippocampal gyrus subregions, the statistics are computed on volumes normalized by their extent in the slice direction [Eq. (1)]. For each label, the table lists the mean and standard deviation of the measurement of interest (volume or normalized volume) in the aMCI (n = 41) and NC (n = 44) groups. These means and standard deviations are computed after the measures are corrected for age and ICV, as described in the text. For each label, the table also gives the t‐statistic for the group difference between NC and aMCI, with age and ICV as covariates (82 degrees of freedom), as well as the corresponding P‐value for a one‐sided alternative hypothesis (aMCI < NC). Lastly, for each label, the table lists the area under the receiving operator characteristic curve (AUC). The AUC reflects the ability of the age and ICV‐corrected measurements to discriminate between aMCI and NC conditions. The radius (half width) of the 95% confidence interval on the AUC, computed using the [DeLong et al., 1988] bootstrap‐based method, is also given for each anatomical label.