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. 2015 Feb 2;6:19. doi: 10.3389/fphys.2015.00019

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Copyright © 2015 Mesirca, Torrente and Mangoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of T-type VGCCs in cardiac automaticity. (A) Representative sweeps of spontaneous action potentials obtained from SAN cells from WT (upper left trace) and Ca_v3.1^−/− mice (lower left trace). Right panel: Superimposition of typical action potentials from a WT and from Ca_v3.1^−/− SAN cell. (B) Histograms of the average bpm value and the slope of the diastolic depolarization (SDD). (C) Representative telemetric ECG recordings obtained on WT (left panel) and Ca_v3.1^−/− animals (right panel). (D) Variation of heart rate (in bpm) in WT (left panel) and Ca_v3.1^−/− mice (right panel) over a 24-h period. Dashed lines indicate mean day and night heart rates (reprinted from Mangoni et al., 2006b with permission from Wolters Kluwer Health).