Table 2. Concentrations of antibodies against Haemophilus influenzae type a and type b and serum bactericidal assay titers in Aboriginal and non-Aboriginal patients in chronic renal failure and comparison groups of healthy persons from the Thunder Bay region, northwestern Ontario, Canada, 2010–2012*.
| Variable | Age-matched comparison groups of healthy Aboriginal persons and those with CRF | Aboriginal CRF patients | Non-Aboriginal CRF patients | Non-Aboriginal healthy comparison group age-matched to non-Aboriginal CRF | Age-matched comparison group regardless of race | CRF patients regardless of race | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. patients |
30 |
30 |
30 |
30 |
60 |
60 |
||||||
| Hia SBA GMT | 268.1 | 147.0 | 49.64 | 104.0 | 167.0 | 85.43 | ||||||
| 95% CI | 132.8–541.4 | 72.9–296.4 | 21.7–113.3 | 49.2–219.7 | 100–278.9 | 49.6–147.2 | ||||||
| p value† |
|
p = 0.22 |
p = 0.045
|
p = 0.18 |
|
p = 0.076 |
|
|||||
| IgM against Hia, GMC | 3.75 | 1.94 | 2.60 | 1.69 | 2.52 | 2.25 | ||||||
| 95% CI | 2.28–6.15 | 1.08–3.50 | 1.69–4.01 | 0.95–3.01 | 1.72–3.69 | 1.57–3.21 | ||||||
| p value |
|
p = 0.086 |
p = 0.42 |
p = 0.23 |
|
p = 0.66 |
|
|||||
| IgG against Hia, GMC | 1.81 | 1.56 | 1.20 | 1.27 | 1.52 | 1.37 | ||||||
| 95% CI | 1.26–2.60 | 1.12–2.17 | 0.89–1.63 | 0.91–1.77 | 1.19–1.93 | 1.10–1.71 | ||||||
| p value |
|
p = 0.53 |
p = 0.25 |
p = 0.81 |
|
p = 0.54 |
|
|||||
| Hib SBA GMT | 181.0 | 23.7 | 15.28 | 25.4 | 67.81 | 19.03 | ||||||
| 95% CI | 84.0–390.2 | 11.09–50.62 | 6.88–33.94 | 11.26–57.30 | 37.21–123.6 | 11.12–32.56 | ||||||
| P value |
|
p = 0.0003
|
p = 0.42 |
p = 0.37 |
|
p = 0.002
|
|
|||||
| IgM against Hib, GMC | 0.11 | 0.04 | 0.08 | 0.04 | 0.07 | 0.06 | ||||||
| 95% CI | 0.069–0.18 | 0.02–0.079 | 0.05–0.12 | 0.02–0.08 | 0.04–0.10 | 0.04–0.08 | ||||||
| p value |
|
p = 0.015
|
p = 0.10 |
p = 0.089 |
|
p = 0.64 |
|
|||||
| IgG against Hib, GMC | 1.63 | 0.61 | 0.62 | 0.87 | 1.19 | 0.61 | ||||||
| 95% CI | 1.06–2.51 | 0.39–0.95 | 0.34–1.11 | 0.61–1.24 | 0.91–1.58 | 0.43–0.88 | ||||||
| p value | p = 0.0018 | p = 0.95 | p = 0.31 | p = 0.004 | ||||||||
*CRF, chronic renal failure; Hia Haemophilus influenzae type a; SBA, serum bactericidal assay; GMT, geometric mean titer; GMC, geometric mean concentration (μg/mL); CI, confidence interval; Hib, Haemophilus influenzae type b. †p values (Student t test [2-sided after log transformation]) are provided between each pairwise comparison. Significance level set at p<0.05; bold text indicates statistically significant p values.