Table 2.
Some reported associations between variants in candidate genes and immune responses to vaccines.
| Vaccine to which immune response was measured | Gene(s) associated with vaccine response | Reference |
|---|---|---|
| Measles | HLA, TLR2–6, DDX58, OAS1, ADAR | (22–25) |
| Hepatitis B | IFNG, MAPK8, IL10RA ITGAL, IL4, IL4R, IL10, HLA, TNF, IL12B | (20, 26–31) |
| Conjugated pneumococcal | IL4, IL4RA, IL13 | (32) |
| Group C meningococcal | TLR3, CD44 | (33) |
| Influenza | HLA | (34) |
| Hib | TIRAP, | (35) |
| Hepatitis A | IL10 | (36) |
| Rubella | HLA, LTA, TNF, LST1 | (37, 38) |
| Diphtheria | IL10 | (28) |
| Tetanus | IL4RA | (28) |
| BCG | TLR1, TLR6 | (19) |
HLA, human leukocyte antigen; TLR, toll like receptor; DDX58, dead box polypeptide 58; OAS1, 2-prime, 5-prime oligoadenylate synthetase 1; ADAR, RNA-specific adenosine aeaminase; IFNG, interferon gamma; MAPK8, mitogen-activated protein kinase 8; ITGAL, integrin alpha L; IL, interleukin; IL-4R, interleukin-4 receptor; TNF, tumor necrosis factor; IL-12B, interleukin-12 beta chain; CD44, cluster of differentiation 44; IL-4RA, interleukin-4 receptor alpha chain; TIRAP, TIR-containing adaptor protein; LTA, lymphotoxin; LST1, leukocyte specific transcript 1.