Table 1.

Studies investigating the role of ABO-group matching in platelet transfusions.

Author	Study type/question	Result	Year	Journal	Reference
Heal et al.	In vitro study investigating the role of circulating immune complexes after ABO-non-identical transfusion	Circulating immune complexes adhere to platelets via Fc-receptor and complement receptors and provide a potential mechanism for platelet clearance	1996	Vox sanguinis	(118)
Blumberg et al.	Retrospective cohort-study investigating patients undergoing cardiac surgery	Patients who received ABO-mismatched platelets had a longer hospital stay, more fever, and more RBC transfusion. Furthermore, there was a trend toward a 75% reduction in mortality with ABO-identical platelets	2001	Transfusion	(119)
Refaai et al.	Retrospective analysis of non-ABO-identical platelet transfusion and the effect on transfusion requirements and other clinical parameters	ABO-identical transfusions might lead to lower transfusion requirements and better clinical outcome	2011	Vox sanguinis	(120)
Henrichs et al.	Feasibility trial, designed to answer if uniform ABO-identical platelet transfusion is doable in a tertiary care hospital setting	97% of patients received ABO-identical platelets. There was an unexpected reduction in febrile and allergic reactions. In addition, there was a reduction in RBC alloimmunization and HLA platelet requirements	2012	Transfusion	(121)
Refaai et al.	In vitro study investigating the effect of anti-A and anti-B on platelet function and clot formation	Anti-A and anti-B inhibit platelet aggregation and reduce clot formation in various in vitro assays	2013	Transfusion	(117)

The table summarizes the in vitro and clinical studies by our group at the University of Rochester investigating the role of the ABO blood group system in platelet transfusions.