Fig. 2.

Heat map showing different expression patterns of 20 top genes with ANOVA p-value < 0.05 and absolute fold change > 6 in lung cancer based on core level gene expression analysis. The heat map indicates up-regulation (red), down-regulation (green), and mean gene expression (black). The columns represent individual tissue samples including five lung cancer samples and one normal control. The rows are labeled with individual gene symbols.

As many as 129,542 genes were analyzed at extended level, and 3411 genes were found to be differentially expressed with absolute fold change > 2 and p-value < 0.05 compared with normal control (Fig. 3). Adjustment of the absolute fold change cutoff to 8 results in a group of 50 genes. Because the detailed information for some of the genes is not available even using the latest Affymetrix annotation file, only 17 genes with designated gene symbols are included in the heat map in Fig. 4.