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. 2015 Jan 6;112(4):1143–1148. doi: 10.1073/pnas.1423952112

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Fig. 2. — Infusion studies with IRASO-treated rats. (A) Hepatic insulin receptor immunoblots, comparing control ASO vs. IRASO groups. (B) Hepatic Akt2 phosphorylation in control ASO treated vs. IRASO treated rats. Overnight fasted rats (Basal) compared with rats subject to a 20-min hyperinsulinemic clamp (Clamp). Bar graphs represent the ratio of phosphorylated Akt2 to total Akt2. , basal group; , clamp group. **P < 0.01. (C) Esterification rates, saline infusion vs. Intralipid infusion. , saline infusion; , Intralipid infusion. Data reported as mean ± SEM.

Inline graphic — Infusion studies with IRASO-treated rats. (A) Hepatic insulin receptor immunoblots, comparing control ASO vs. IRASO groups. (B) Hepatic Akt2 phosphorylation in control ASO treated vs. IRASO treated rats. Overnight fasted rats (Basal) compared with rats subject to a 20-min hyperinsulinemic clamp (Clamp). Bar graphs represent the ratio of phosphorylated Akt2 to total Akt2. , basal group; , clamp group. **P < 0.01. (C) Esterification rates, saline infusion vs. Intralipid infusion. , saline infusion; , Intralipid infusion. Data reported as mean ± SEM.