Fig. 1.
Yki activates JNK signaling in Drosophila. Third instar wing discs are shown. Ectopic Yki activates JNK target puc expression. puc-LacZ expression is shown in sd > GFP control (A), sd>HepWT (B), and sd > Yki (C) wing discs. Compared with control clones (D and H), impaired Hippo signaling activates MMP1 expression and JNK phosphorylation in wts mutant clones (E and I), or clones expressing Yki (F and J) or YkiS168A (G and K). Clones were labeled by the presence (D, F, G, H, J, and K) or absence (E and I) of GFP expression. See also Figs. S1 and S2.