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. 2015 Jan 12;112(4):1131–1136. doi: 10.1073/pnas.1424012112

Table 1.

GSEA comparing differential RNA and protein expression patterns observed for MCF-10A-H1047R vs. MCF-10A with previously established breast cancer signatures

Gene set* Size NES P Dataset
SMID BREAST CANCER BASAL UP 446 1.59 0 RNAseq
SMID BREAST CANCER BASAL DN 434 −1.2 0 RNAseq
SMID BREAST CANCER NORMAL LIKE UP§ 178 1.5 0.003 RNAseq
SMID BREAST CANCER ERBB2 UP 97 1.32 0.071 RNAseq
SMID BREAST CANCER LUMINAL B UP# 99 −1.34 0.056 RNAseq
SMID BREAST CANCER LUMINAL B DNǁ 287 1.96 0 RNAseq
SMID BREAST CANCER BASAL UP 149 1.51 0.006 SILAC
SMID BREAST CANCER BASAL DN 113 1.3 0.049 SILAC
SMID BREAST CANCER NORMAL LIKE UP 32 1.72 0 SILAC
SMID BREAST CANCER ERBB2 UP 47 1.69 0 SILAC
SMID BREAST CANCER LUMINAL B UP 26 −1.11 0.318 SILAC
SMID BREAST CANCER LUMINAL B DN 98 1.64 0 SILAC

Size represents number of genes. DN, DOWN; NES, normalized enrichment score.

*

As listed in the MSigDB (www.broadinstitute.org/gsea/msigdb).

Genes up-regulated in the basal subtype of breast cancer (36).

Genes down-regulated in the basal subtype of breast cancer (36).

§

Genes up-regulated in the normal-like subtype of breast cancer (36).

Genes up-regulated in ERBB2+ breast cancer (36).

#

Genes up-regulated in the luminal B subtype of breast cancer (36).

ǁ

Genes down-regulated in the luminal B subtype of breast cancer (36).