Fig. 3.

Comparison of cancer therapies. For the parameter setting of Fig. 2D, different therapies are compared via 1,000 forward simulations with $K={10}^4$. Shown is the fraction of runs that have not yet developed a metastasis mutation as a function of elapsed time. All-out maximum dosage therapy $\left(u\equiv 1\right)$ is only slightly better than no therapy $\left(u\equiv 0\right)$ in avoiding metastasis. Much better is metronome therapy with ${\tau }_{\text{on}}={\tau }_{\text{off}}=0.1\hspace{0.17em}K\hspace{0.17em}\text{generations},$ with almost 70% success rate (values numerically optimized). Adaptive therapy removes the tumor in close to 90% of runs.