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. 2015 Jan 12;112(4):1196–1201. doi: 10.1073/pnas.1416196112

Fig. 1.

Fig. 1.

Group II mGlu LTD in mouse mPFC. (A and B) Average time course of fEPSP slopes recorded from layer V mPFC. Application of LY379268 at 30 nM (n = 6) and 100 nM (n = 7) transiently decreased the slope, but induced LTD only at 100 nM. (C) Paired-pulse ratio analysis for fEPSPs recorded from all slices in B. x-axis labels correspond to the time-points Inset in B. Insets show sample paired-pulse fEPSP traces from baseline (1) and 60 min after drug washout (4). (D) LTD induced by LY379268 was not altered by the NMDA receptor antagonist AP5 (n = 5). (E) LTD was blocked by a selective mGlu2/3 orthosteric antagonist LY341495 (n = 6). (F) Quantification of LTD measured 55–60 min after drug washout (average of shaded region in A, B, D, and E). * indicates P < 0.05 Tukey posttest vs. 30 nM and 500 nM LY341495. Data are expressed as mean ± SEM.