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. Author manuscript; available in PMC: 2015 Feb 2.
Published in final edited form as: Semin Oncol. 2011 Feb;38(1):3–15. doi: 10.1053/j.seminoncol.2010.11.010

Figure 2.

Figure 2

Lysine-rich protein (LRP) as an MR-CEST reporter. (Top) Illustration of the chemical exchange saturation transfer (CEST) contrast mechanism. A frequency-selective radiofrequency pulse is used to label (green) the amide protons of the contrast agent. Only labeled protons exchange with water protons. This leads to a reduction in MR signal intensity. (Bottom) CEST difference map (right) overlaid on an anatomical MR image (left). This map demonstrates that LRP-expressing xenografts can be distinguished from mock-transfected controls. Reprinted with permission from Macmillan Publishers Ltd: Nature Biotechnology,56 copyright 2007.