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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Nat Med. 2014 Oct 19;20(12):1472–1478. doi: 10.1038/nm.3733

Figure 3. Low VAF blood-specific, hotspot mutations identified in the TCGA and WHISP cohorts using a readcount based approach.

Figure 3

Blood-specific mutations identified by the variant detection pipeline are in blue. An additional 14 blood-specific events (13 shown in green) with VAFs between 2% and 10% were identified in the TCGA samples and their positive associations with older ages were confirmed. 13 hotspot variants were identified in WHISP samples (n = 557) and seven (in green) have variant allele fractions ranging from 2% to ~10%. One JAK2 V617F identified in a TCGA sample was not shown due to a VAF higher than 50%. (a) DNMT3A R882C, (b) DNMT3A R882H, (c) GNAS R202H, (d) JAK2 V617F, and (e) SF3B1 K700E.