Fig. 1.

Prevalence of Aβ+ CNs across the lifespan. Data across multiple studies are plotted by sample age and percent classified as Aβ+ (a total of 3512 subjects from post-mortem studies and 2034 from amyloid-imaging studies are represented). The area of each bubble is scaled by group size, ranging from 12 to 639 CNs (for studies reporting Aβ+ prevalence across multiple age groups, multiple bubbles are used). Although Aβ+ classification is study specific, a consistent pattern emerges. These studies reveal a low proportion of Aβ+ CNs younger than 60, followed by a linear increase in the proportion of Aβ+ CNs after age 60 (~30 % of CNs are Aβ+ at age 75). Post-mortem studies and Aβ+ classification are as follows: A/black = Braak & Braak (CERAD B & C, N=2661) (Braak and Braak 1997); B/red = Kok et al. (CERAD moderate and frequent, N=534) (Kok et al. 2009); C/light blue = Savva et al. (CERAD moderate and severe, N=183) (Savva et al. 2009); D/pink = Bennett et al., Religious Orders Study (CERAD probable and definite, N=98) (Bennett et al. 2006); E/dark blue = Bennett et al., Memory and Aging Project (CERAD probable and definite, N=36) (Bennett et al. 2006). Amyloid PET studies and Aβ+ classification are as follows: 1/purple = Knopman et al. (>1.5 PIB SUVR with gray matter cerebellum, N=806) (Knopman et al. 2014); 2/orange = Morris et al. (>0.18 PIB Binding Potential with gray matter cerebellum, N=241) (Morris et al. 2010); 3/yellow = Johnson et al. 2014 (florbetapir qualitative read; N=201) (Johnson et al. 2014), 4/dark green = Rowe et al. (>1.5 PIB SUVR with gray matter cerebellum, N=183) (Rowe et al. 2013), 5/hot pink = Mormino et al. 2014, Alzheimer’s Disease Neuroimaging Initiative Phase 2 study (>1.126 florbetapir SUVR gray and white matter cerebellum, N = 198) (Mormino et al. 2014), 6/green = Mormino et al. 2014, Harvard Aging Brain Study (>1.196 PIB SUVR gray and white matter cerebellum, N=161) (Mormino et al. 2014); 7/dark red = Mathis et al. 2013 (>1.57 PIB SUVR gray matter cerebellum, N=152) (Mathis et al. 2013); 8/brown = Wirth et al. 2014 (>1.12 PIB DVR gray matter cerebellum, N=92) (Wirth et al. 2014)