| Bone marrow |
|
|
|
|
| Proteasome (Prosome Macropain) 26S Subunit, ATPase, 5 (PSMC5): |
Decreased in p53+ treated |
P62196 |
Protein turnover, negative regulation of transcription. |
26S proteasome involved in degradation of ubiquitinated p53 [54] |
| 40S ribosomal protein SA (RPSA): |
Decreased in p53+ treated |
P14206 |
40S ribosomal subunit assembly, laminin receptor, cell fate determination and tissue morphogenesis. |
|
| Actin-related protein 2/3 Complex, Subunit 5, 16 kDa (ARPC5): |
Decreased in p53+ treated |
Q9CPW4 |
Actin polymerization, cilium biogenesis/degradation |
|
| Alpha enolase: |
Decreased in p53+ treated Increased in Δ 122p53 |
P17182 |
Multifunctional enzyme, glycolysis, growth control, hypoxia tolerance, inflammation* |
|
| Creatine kinase M-type (CKM): |
Decreased in p53+ treated |
P07310 |
Phosphocreatine biosynthesis |
|
| Eukaryotic translation initiation factor 4H (EIF4H): |
Decreased in p53+ treated |
Q9WUK2 |
Protein biosynthesis |
|
| F-actin capping protein subunit beta (CAPZB): |
Decreased in p53+ treated |
P47757 |
Actin filament growth, cell morphology and cytoskeletal organization |
Interacts with p53 [55] |
| Ferritin light chain 1: |
Decreased in mΔ pro treated |
P29391 |
Iron storage and homeostasis |
|
| Plastin-2 (LCP1): |
Decreased in p53+ treated |
Q61233 |
T-cell activation, actin filament bundle assembly, organ regeneration, and intracellular protein transport |
|
| Proteasome subunit alpha type-1 (PSMA1): |
Decreased in p53+ treated |
Q9R1P4 |
Protein turnover, negative regulation of inflammation |
26S proteasome involved in degradation of ubiquitinated p53 [54] |
| T-complex protein 1 subunit epsilon (CCT5) : |
Decreased in Δ 122p53 |
P80316 |
Molecular chaperone, and ciliogenesis |
p53 binds to CCT complex, required for correct p53 folding [56] |
| Transgelin (TAGLN): |
Increased in Δ 122p53 |
P37804 |
Organ development |
|
| Triosephosphate isomerase (TPI1) |
Decreased in p53+ treated |
P17751 |
Gluconeogenesis, glycolysis, pentose phosphate pathway |
|
| Thymus |
|
|
|
|
| Annexin A5 (ANXA5): |
Increased in p53+ treated Decreased in Δ 122p53 |
P48036 |
Anticoagulant |
|
| ATP synthase subunit beta, mitochondrial (ATP5B): |
Increased in p53+ treated |
P56480 |
ATP synthesis, ion transport |
|
| Elongation factor 2 (EEF2): |
Increased in p53+ treated |
P58252 |
Protein biosynthesis |
Interacts with p53 [57] |
| F-actin capping protein subunit beta (CAPZB): |
Increased in p53+ treated |
P47757 |
Actin filament growth, cell morphology and cytoskeletal organization |
Interacts with p53 [55] |
| Heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90-beta) |
Increased in Δ 122p53, mΔ pro, and p53- |
P11499 |
Molecular chaperone |
Interacts with p53 [58]. p53 reduces HSP90AB1 expression [59] |
| Heterogeneous nuclear ribonucleoprotein K (HNRNPK): |
Increased in p53+ treated Increased in Δ 122p53 untreated |
P61979 |
Transcription regulation, and mRNA processing and splicing |
Transcriptional co-factor for p53 mediated gene transcription [60, 61, 63] |
| Lamin-B1 (LMNB1): |
Increased in p53+ treated |
P14733 |
Regulation of JNK signaling and G2/M procession |
Senescence induced by Lamin B is reversed upon p53 inactivation [62] |
| Proteasome subunit alpha type-1 (PSMA1): |
Increased in p53+ treated |
Q9R1P4 |
Protein turnover, negative regulation of inflammation |
26S proteasome involved in degradation of ubiquitinated p53 [54] |
| Proteasome subunit alpha type-3 (PSMA3): |
Increased in p53+ treated |
O70435 |
Protein turnover |
26S proteasome involved in degradation of ubiquitinated p53 [54] |
| Proteasome subunit beta type 8 (PSMB8): |
Increased in p53+ treated |
P28063 |
Antigen processing and presentation, and proteolysis |
26S proteasome involved in degradation of ubiquitinated p53 [54] |
| Transketolase (TKT): |
Increased in Δ 122p53 |
P40142 |
Pentose phosphate pathway |
|
| Translationally-controlled tumor protein (TPT1): |
Decreased in p53+ treated. Increased in Δ 122p53 |
P63028 |
Allergy response, anti-apoptosis, and cell cycle regulation |
Interacts with p53 [63, 64]. Is a transactivation target of p53 [64] |
| Tropomyosin alpha-1 chain (TPM1): |
Increased in p53+ treated |
P58771 |
Cardiac muscle contraction, and stabilizing cytoskeleton actin filaments |
|
| 14–3–3 protein epsilon(14–3–3E): |
Increased in Δ 122p53, mΔ pro, and p53- |
P62259 |
Adapter protein |
14–3–3 proteins interact with p53 [65, 66] |
| 14–3–3 protein eta |
Increased in p53+ treated |
P68510 |
Adapter protein |
|
| 14–3–3 protein gamma |
Increased in p53+ treated |
P61982 |
Adapter protein |
|
| 14–3–3 protein zeta/delta |
Increased in p53+ treated |
P63101 |
Adapter protein |
|
| Lung |
|
|
|
|
| Aldehyde dehydrogenase mitochondrial (ALDH2): |
Decreased in p53+ treated Increased in Δ 122p53 |
P47738 |
Metabolism |
|
| 26S proteasome non-ATPase regulatory subunit 3 (PSMD3): |
Increased in p53+ treated |
P14685 |
Protein turnover |
26S proteasome involved in degradation of ubiquitinated p53 [54] |
| Destrin |
Increased in p53+ treated |
Q9R0P5 |
Actin filament depolymerization |
|
| Valosin containing protein (VCP): |
Decreased in p53+ treated. Increased in Δ 122p53 |
Q01853 |
DNA damage and repair |
Interacts with p53 [48] |
