Table 2.
Reported cases of MASC§
| Age (year) | Sex | Location | Size (greatest dimension)/Pathologic Features | Reference/Remarks |
|---|---|---|---|---|
| 41 | F | Hard and soft palate | 1.8 cm/Uncerated mass, predominantly solid with microcystic component, high-grade features present | Current case |
| ATD: PNI+/DI-/M+*, lymphovascular invasion identified | ||||
| Leg. 1 | Leg. 1 | Oral cavity not specified | 1.8 cm/Macrocstic | 2012 Connor et al. |
| ATD:PNI-/DI+/N-/M- | ||||
| Leg. 1 | Leg. 1 | Parotid | 3.0 cm/Solid | 2012 Connor et al. |
| ATD: PNI-/DI-/N-/M- | ||||
| Leg. 1 | Leg. 1 | Submandibular | 1.8 cm/Solid | 2012 Connor et al. |
| ATD: PNI+/DI+/N-/M- | ||||
| Leg. 1 | Leg. 1 | Oral cavity roof of mouth | 0.5 cm/Solid exophytic polyp | 2012 Connor et al. |
| ATD: PNI+/DI+/N-/M- | ||||
| Leg. 1 | Leg. 1 | Oral cavity inner cheek | NA/Mixed solid and cystic | 2012 Connor et al. |
| ATD: PNI-/DI-/N-/M- | ||||
| Leg. 1 | Leg. 1 | Parotid | 2.9 cm/Mixed solid and cystic | 2012 Connor et al. |
| ATD: PNI+/DI-/N-/M- | ||||
| Leg. 1 | Leg. 1 | Lip | 1.2 cm/Solid | 2012 Connor et al. |
| ATD: PNI+/DI+/N-/M- | ||||
| 37 | F | Parotid, deep lobe | 2.0 cm/Microcystic, cribiform, and tubular, FNA was performed | 2012 Ito et al. |
| ATD: PNI+/DI+/N-/M- | ||||
| Leg. 2 | F | Leg. 2 | All cases were originally diagnosed as AciCC. See Leg. 2 for details. | 2012 Seethala et al. |
| Leg. 2 | M | Leg. 2 | All cases were originally diagnosed as AciCC. See Leg. 2 for details. | 2012 Seethala et al. |
| Leg. 2 | M | Leg. 2 | All cases were originally diagnosed as AciCC. See Leg. 2 for details. | 2012 Seethala et al. |
| Leg. 2 | M | Leg. 2 | All cases were originally diagnosed as AciCC. See Leg. 2 for details. | 2012 Seethala et al. |
| Leg. 2 | M | Leg. 2 | All cases were originally diagnosed as AciCC. See Leg. 2 for details. | 2012 Seethala et al. |
| Leg. 2 | M | Leg. 2 | All cases were originally diagnosed as AciCC. See Leg. 2 for details. | 2012 Seethala et al. |
| Leg. 2 | M | Leg. 2 | All cases were originally diagnosed as AciCC. See Leg. 2 for details. | 2012 Seethala et al. |
| Leg. 2 | M | Leg. 2 | All cases were originally diagnosed as AciCC. See Leg. 2 for details. | 2012 Seethala et al. |
| Leg. 2 | M | NA | All cases were originally diagnosed as AciCC. See Leg. 2 for details. | 2012 Seethala et al. |
| 69 | F | Parotid | 3.0 cm/Microcystic, tubular, papillary, and solid, FNA was performed | 2012 Pisharodi et al. |
| ATD: PNI-/DI: ND/N-/M- | ||||
| 48 | F | Upper lip (submucosal) | 1 cm/Microcystic | 2012 Kratochvil et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 52 | M | Lower lip (submucosal) | 0.7 cm/Cribiform, follicular | 2012 Kratochvil et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 44 | M | Upper lip (submucosal) | 0.3 cm/Microcystic | 2012 Kratochvil et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 34 | F | Upper lip | 1.5 cm/Tubular, follicular, microcystic and macrocystic | 2013 Laco et al. |
| ATD: PNI: ND/DI: -/M: - | ||||
| 58 | M | Parotid | 2.0 cm/Tubular, follicular, microcystic and macrocystic | 2013 Laco et al. |
| ATD: PNI: ND/DI: -/M: - | ||||
| 71 | M | Buccal | 1.0 cm/Original diagnosis was AciCC, see Leg. 3 for details. | 2013 Bishop et al. |
| 25 | F | Hard palate | NA/Original diagnosis was AciCC, see Leg. 3 for details. | 2013 Bishop et al. |
| 20 | F | Soft palate | 0.9 cm/Original diagnosis was AciCC, see Leg. 3 for details. | 2013 Bishop et al. |
| 86 | F | Soft palate | 1.0 cm/Original diagnosis was AciCC, see Leg. 3 for details. | 2013 Bishop et al. |
| 79 | F | Soft palate | 0.7 cm/Original diagnosis was AciCC, see Leg. 3 for details. | 2013 Bishop et al. |
| 62 | F | Upper lip | 0.3 cm/Original diagnosis was AciCC, see Leg. 3 for details. | 2013 Bishop et al. |
| 71 | M | Upper lip | 0.6 cm/Original diagnosis was AciCC, see Leg. 3 for details. | 2013 Bishop et al. |
| 59 | M | Lower lip | 0.9 cm/Original diagnosis was AciCC, see Leg. 3 for details. | 2013 Bishop et al. |
| 68 | M | Lower lip | 0.5 cm/Original diagnosis was AciCC, see Leg. 3 for details. | 2013 Bishop et al. |
| 34 | F | Submandibular gland | 0.9 cm/Original diagnosis was AciCC, see Leg. 3 for details. | 2013 Bishop et al. |
| 36 | F | Submandibular gland | 2.0 cm/Original diagnosis was AciCC, see Leg. 3 for details. | 2013 Bishop et al. |
| 58 | F | Parotid, deep lobe | 2.0 cm/Solid, cribiform, microcystic and macrocystic, FNA was performed | 2013 Sethi et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 53 | M | Parotid | 3.0 cm/Micropapillary, microcystic, and solid, original diagnosis was AciCC | 2013 Pinto et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 29 | M | Parotid | 1.8 cm/Micropapillary, microcystic, and solid, original diagnosis was AciCC | 2013 Pinto et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 61 | F | Parotid | 3.0 cm/Micropapillary, microcystic, and solid, original diagnosis was AciCC | 2013 Pinto et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 51 | F | Bucal mucosa | 1.0 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 44 | F | Parotid | 0.9 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/N-/M- | ||||
| 48 | M | Soft palate | 1.5 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| The patient developed metastasis and died of disease 4 after two years after initial diagnosis. | ||||
| 55 | M | Parotid | 5.5 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/N: +/M: - | ||||
| 34 | M | Parotid | 1.6 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 53 | M | Parotid | 1.5 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 53 | M | Parotid | 3.5 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| The patient has multiple recurrence and died of disease after 6 years | ||||
| 55 | F | Parotid | 1.0 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| Multiple recurrence | ||||
| 26 | M | Parotid | 1.5 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 35 | F | Parotid | 3.0 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 46 | M | Parotid | 1.4 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/M: - | ||||
| 55 | M | Parotid | 4.0 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/M: - | ||||
| 59 | F | Parotid | Size not available/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/M: - | ||||
| 21 | F | Parotid | 2.7 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/M: - | ||||
| 75 | F | Parotid | 0.7 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/M: - | ||||
| 32 | M | Upper lip | 1.0 cm/Leg. 4 | 2010 Skálová et al. |
| ATD: PNI: ND/DI: ND/M: - | ||||
| Lymph node metastasis at 86 months after diagnosis, no evidence of disease for 27 months after treatment | ||||
| 34 | F | Parotid | 1.0 cm/follicular and microcystic | 2012 Levine et al. |
| ATD: PNI: ND/DI: ND/M: - | ||||
| Mammoglobin positive, no translocation confirmed by FISH | ||||
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Parotid | Leg. 5 | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Submandibular gland | Leg. 5, originally diagnosed as ANOS | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Submandibular gland | Leg. 5, originally diagnosed as ANOS | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Submandibular gland | Leg. 5, originally diagnosed as ANOS | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Soft palate | Leg. 5, originally diagnosed as ANOS | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Soft palate | Leg. 5, initial diagnosis was MASC | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Soft palate | Leg. 5, initial diagnosis was MASC | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Buccal mucosa | Leg. 5, initial diagnosis was MASC | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Buccal mucosa | Leg. 5, initial diagnosis was MASC | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Base of tongue | Leg. 5, originally diagnosed as ANOS | 2012 Seethala et al. |
| Leg. 5 | Leg. 5 | Upper lip | Leg. 5, initial diagnosis was MASC | 2012 Seethala et al. |
| 71 | F | Soft Palate | Leg. 6 | 2011 Fehr et al. |
| 23 | F | Parotid | Leg. 6 | 2011 Fehr et al. |
| 70 | F | Parotid | Leg. 6 | 2011 Fehr et al. |
| 43 | M | Oral mucosa | Leg. 6 | 2011 Fehr et al. |
| 37 | F | Parotid | 0.5 cm/originally diagnosed as salivary adenoma | 2013 Choisea et al. |
| Leg. 7 | M | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | M | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | M | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | M | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | M | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | M | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | M | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | M | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | F | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | F | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | F | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | F | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| Leg. 7 | F | 11 parotid/2 non-parotid | Leg. 7 | 2013 Jung et al. |
| 51 | F | Parotid | 2.5 cm/FNA performed | 2013 Griffith et al. |
| Reported twice (R03, R12) | ATD: PNI: ND/DI: ND/N: -/M: - | |||
| 51 | M | Buccal mucosa | 2.1 cm/FNA performed | 2013 Griffith et al. |
| Reported twice (R03, R12) | ATD: PNI: ND/DI: ND/N: -/M: - | |||
| 27 | M | Parotid | 1.0 cm/FNA performed | 2013 Griffith et al. |
| Reported twice (R03, R12) | ATD: PNI: ND/DI: ND/N: -/M: - | |||
| 44 | F | Submandibular gland | 1.8 cm/FNA performed | 2013 Griffith et al. |
| ATD: PNI: ND/DI: ND/N: +/M: - | ||||
| 23 | F | Parotid | 1.2 cm/FNA performed | 2013 Griffith et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| 66 | M | Parotid | NA/FNA performed | 2013 Griffith et al. |
| ATD: PNI: ND/DI: ND/N: -/M: - | ||||
| Unknown | M | Parotid | 2.2 cm/originally diagnosed as AicCC | 2012 Choisea et al. |
| 41 | F | Hard palate | 0.4 cm/originally diagnosed as mucoepidermoid carcinoma | 2012 Choisea et al. |
| 36 | M | Submandibular gland | 2.5 cm/Solid, microcystic and macrocystic growth pattern, FNA performed | 2012 Yan et al. |
| 14 | F | Parotid | 3.0 cm/ | 2013 Melin-Aldana et al. |
| ATD: PNI: ND/DI: ND/N: +/M: - (metastasis in a periparotid lymph node) | ||||
| 55 | M | Parotid | 8.0 cm | 2014 Skálová A et al. |
| ATD: PIN: ND/DI: ND/N: -/M: -/high-grade histology | ||||
| Recurred locally 6 years later. | ||||
| 61 | M | Parotid | 4 cm/FNA performed | 2014 Skálová A et al. |
| ATD: PIN+/DI: ND/N+/M+ (single metastatic focus in adipose tissue of the neck) | ||||
| Patient died of disseminated disease after 20 months | ||||
| 73 | M | Parotid | Size is unknown, originally diagnosed as a monomorphic adenoma | 2014 Skálová A et al. |
| Recurrence for 4 times and the patient died 4 years after the primary surgery | ||||
| 43 | F | Submandibular gland | Microcystic, tubular and solid | 2014 Shah AA et al. |
| 23 | F | Parotid | 1.2 cm/FNA performed | 2014 Shah AA et al. |
| Microcyctic and pseudopapillary | ||||
| 34 | F | Periparotid lymph node | Microcystic, macrocystic, solid and papillary | 2014 Shah AA et al. |
| 76 | F | Parotid | Microcystic, macrocystic, and papillary | 2014 Shah AA et al. |
| 71 | M | Parotid | Microcystic and macrocystic | 2014 Shah AA et al. |
| 55 | F | Parotid | Macrocystic and solid | 2014 Shah AA et al. |
| 16 | F | Parotid | Microcystic and solid | 2014 Shah AA et al. |
| 22 | M | Parotid | Microcystic, macrocystic and solic | 2014 Shah AA et al. |
| 26 | M | Parotid | Predominently papillary and pseudopapillary with focal microcystic areas | 2014 Shah AA et al. |
| 56 | M | Parotid | Papillary, microcystic and macrocystic | 2014 Shah AA et al. |
| 45 | F | Parotid | Microcystic, macrocystic and focal papillary | 2014 Shah AA et al. |
| 37 | F | Parotid | Macrocystic and focally microcystic | 2014 Shah AA et al. |
| 53 | M | Parotid | Microcystic and solid | 2014 Shah AA et al. |
| 46 | F | Parotid | Microcystic and solid | 2014 Shah AA et al. |
| 56 | M | Parotid | Microcystic, macrocystic, papillary and pseudopapillary | 2014 Shah AA et al. |
| 28 | F | Parotid | Microcystic, tubular and solid | 2014 Shah AA et al. |
| Unknown | F | Parotid | Microcystic, tubular and solid | 2014 Shah AA et al. |
| 66 | F | Parotid | Microcystic and solid | 2014 Shah AA et al. |
| 53 | M | Submandibular | Microcystic, macrocystic, tubular and solid | 2014 Shah AA et al. |
§
Unless otherwised stated in the table, ETV6-NTRK3 translocation is confirmed by FISH;
ATD: At the time of diagnosis; PNI: Perineural invasion; DI: Duct involvement; N: Metastasis to cervical lymph nodes or periparotid lymph node; M: Distant metastasis;
*
Unless otherwise specified, lymphovascular invasion is described in the original report;
NA: Not available; ND: Not described in original report; FNA: Fine needle aspiration; Leg. 1: In this study, the age range was 14 to 77 years (mean, 40 y) with 6 males and 1 female. Further demographic details were not provided in the original publication. Leg. 2: A total of 10 cases were described (8 males, 2 females). The average age was 45.5 years but detailed distribution of age was not provided. There were metastases in 2 out of the 6 cases who received lymph node dissection. All cases were originally diagnosed as acinic cell carcinoma (AciCC). The locations of the tumors were not provided. Since AciCC is most common in parotid gland, the location of these tumors can be assumed to be predominantly the parotid gland. The status for perineural invasion, ductal involvement, and metastases were not provided in the original report. Leg. 3: Perineural invasion was identified in 1 cases but lymphovascular invasion was not identified. Ductal involvement or metastases were not described in the original report. Leg. 4: These tumors were originally diagnosed as acinic cell carcinoma, adenoid cystic carcinoma, cysadenocarcinoma, and low-grade carcinoma not otherwise specified. Leg. 5: The average age in this study was 45.7 years and a male to female ratio of 1.4:1. The average tumor sizes were 1.9 and 2.5 cm respectively depending on whether it is referral or in-house cases respectively. Four cases showed metastases, three cases showed recurrence, and one of the metastatic case resulted in death from disease. Many of these tumors were diagnosed as AciCC, ANOS, mucin secreting signet ring cell carcinoma, and mucoepidermoid carcinoma. Leg. 6: The sizes of tumor and original diagnoses, of these cases were not available in the original report. There was no description of perineural invasion, lymphovascular invasion, lymph node or distant metastasis in the original report. Leg. 7: The age of the cases in this study ranged from 17 to 76 year-old (average is 46.4) cm. The size ranged from 0.7 to 2.5 cm (average 17.7 cm). This is also the first of four cases with high-grade histology. This study also described 10 cases that possessed histologic features of MASC but no ETV6-NTRK3 translocation and these cases were classified as MASC-mimickers. No immunohistochemistry for mammoglobin was performed in this study.