Table 2.
Summary of pathological features and clinical courses in patients with IDLGGs (n = 23)
| Case No. | Symptoms | Sex | Age | Preop KPS | Resection extent | Pathology | IDH1/2 | IHC of IDHR132H | 1p19q status | TERT promoter | Postop KPS | RT | CHT | Recurrence | EFS (Years) | Death | OS (Years) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Trauma | M | 35 | 100 | CR | AII | Mut | Positive | intact | Wt | 100 | Y | Y | N | 9.2 | N | 9.2 |
| 2 | Trauma | M | 45 | 100 | CR | OAII | Mut | Positive | co-deleted | Mut | 100 | N | Y | N | 9.8 | N | 9.8 |
| 3 | Dizziness | M | 27 | 100 | ICR | OAII | Mut | Positive | co-deleted | Mut | 100 | Y | Y | N | 8.8 | N | 8.8 |
| 4 | Trauma | M | 34 | 100 | CR | OAII | Mut | Positive | co-deleted | Mut | 0 | Y | Y | Y | 9.0 | Y | 10.0 |
| 5 | Health checkup | M | 48 | 100 | CR | OII | Mut | Positive | co-deleted | Mut | 20 | Y | Y | Y | 9.0 | N | 10.3 |
| 6 | Headache | F | 42 | 90 | CR | OAII | Mut | Positive | co-deleted | Wt | 100 | Y | Y | N | 10.7 | N | 10.7 |
| 7 | Trauma | F | 60 | 100 | CR | AII | Mut | Positive | intact | Wt | 100 | Y | Y | N | 8.4 | N | 8.4 |
| 8 | Dizziness | F | 32 | 100 | CR | OII | Mut | Positive | intact | Mut | 100 | Y | Y | N | 12.3 | N | 12.3 |
| 9 | Dizziness | M | 37 | 100 | CR | OAII | Mut | Positive | co-deleted | Mut | 0 | Y | Y | Y | 5.7 | Y | 6.2 |
| 10 | Dizziness | M | 50 | 100 | CR | OAII | Mut | Positive | co-deleted | Wt | 100 | Y | N | N | 10.3 | N | 10.3 |
| 11 | Trauma | F | 37 | 100 | CR | AII | Mut | Positive | co-deleted | Wt | 0 | U | U | Y | 3.3 | Y | 3.9 |
| 12 | Trauma | F | 34 | 100 | CR | AII | Mut | Positive | intact | Wt | 100 | Y | Y | N | 10.4 | N | 10.4 |
| 13 | Headache | M | 37 | 90 | CR | OAII | Mut | Positive | co-deleted | Mut | 100 | Y | N | N | 7.7 | N | 7.7 |
| 14 | Dizziness | F | 55 | 100 | CR | OII | Mut | Positive | 1p loss | Wt | 0 | U | U | Y | 2.8 | Y | 3.3 |
| 15 | Trauma | M | 47 | 100 | CR | OII | Mut | Positive | co-deleted | Mut | 100 | Y | Y | N | 9.3 | N | 9.3 |
| 16 | Trauma | F | 35 | 100 | CR | OAII | Mut | Positive | co-deleted | Mut | 100 | Y | Y | N | 8.0 | N | 8.0 |
| 17 | Trauma | M | 79 | 100 | ICR | AII | Mut | Positive | intact | Wt | 0 | Y | Y | Y | 4.0 | Y | 4.4 |
| 18 | Headache | F | 40 | 100 | CR | OAII | Wt | Negative | intact | Wt | 100 | Y | Y | N | 10.0 | N | 10.0 |
| 19 | Headache | F | 42 | 100 | CR | OII | Mut | Positive | co-deleted | Wt | 100 | Y | Y | N | 10.0 | N | 10.0 |
| 20 | Trauma | M | 57 | 100 | CR | OAII | Mut | Positive | co-deleted | Wt | 100 | N | Y | N | 7.9 | N | 7.9 |
| 21 | Headache | F | 28 | 90 | CR | OII | Mut | Positive | co-deleted | Mut | 90 | Y | Y | N | 11.5 | N | 11.5 |
| 22 | Dizziness | M | 37 | 100 | CR | AII | Mut | Positive | co-deleted | Wt | 100 | Y | Y | N | 11.8 | N | 11.8 |
| 23 | Trauma | M | 26 | 100 | CR | OAII | Mut | Positive | co-deleted | Wt | 90 | Y | Y | N | 8.3 | N | 8.3 |
M = male; F = female; CR = complete resection; ICR = incomplete resection; AII = WHO grade II astrocytoma; OII = WHO grade II oligodendroglioma; OAII = WHO grade II Oligoastrocytoma; Mut = mutation; Wt = wile-type; IHC = immunohistochemistry; Y = yes; N = no; U = unknown; RT = radiation therapy; CHT = chemotherapy; EFS = event-free survival; OS = overall survival.