Table 3.
Expression of ROS-related proteins in the tumor cell compartment of breast cancer metastasis according to the metastatic sites
| Parameters | Total n = 143 (%) | Bone metastasis n = 38 (%) | Brain metastasis n = 37 (%) | Liver metastasis n = 16 (%) | Lung metastasis n = 52 (%) | P-value |
|---|---|---|---|---|---|---|
| Cancer cell compartment | ||||||
| Catalase | 0.012 | |||||
| Negative | 75 (52.4) | 27 (71.1) | 21 (56.8) | 8 (50.0) | 19 (52.4) | |
| Positive | 68 (47.6) | 11 (28.9) | 16 (43.2) | 8 (50.0) | 68 (47.6) | |
| GSTπ | 0.051 | |||||
| Negative | 102 (71.3) | 31 (81.6) | 28 (75.7) | 13 (81.2) | 30 (57.7) | |
| Positive | 41 (28.7) | 7 (18.4) | 9 (24.3) | 3 (18.8) | 22 (42.3) | |
| TxNIP | 0.126 | |||||
| Negative | 126 (88.1) | 34 (89.5) | 36 (97.3) | 14 (87.5) | 42 (80.8) | |
| Positive | 17 (11.9) | 4 (10.5) | 1 (2.7) | 2 (12.5) | 10 (19.2) | |
| MnSOD | 0.198 | |||||
| Negative | 5 (3.5) | 1 (2.6) | 3 (8.1) | 1 (6.2) | 0 (0.0) | |
| Positive | 138 (96.5) | 37 (97.4) | 34 (91.9) | 15 (93.8) | 52 (100.0) | |
| ROS status | 0.001 | |||||
| Non-activated | 113 (79.0) | 35 (92.1) | 32 (86.5) | 14 (87.5) | 32 (61.5) | |
| Activated | 30 (21.0) | 3 (7.9) | 5 (13.5) | 2 (12.5) | 20 (38.5) | |
| Stromal cell compartment | ||||||
| Catalase | 0.080 | |||||
| Negative | 130 (90.9) | 31 (81.6) | 36 (97.3) | 14 (87.5) | 49 (94.2) | |
| Positive | 13 (9.1) | 7 (18.4) | 1 (2.7) | 2 (12.5) | 3 (5.8) | |
| GST π | < 0.001 | |||||
| Negative | 99 (69.2) | 21 (55.3) | 32 (86.5) | 4 (25.0) | 42 (80.8) | |
| Positive | 44 (30.8) | 17 (44.7) | 5 (13.5) | 12 (75.0) | 10 (19.2) | |
| TxNIP | 0.623 | |||||
| Negative | 142 (99.3) | 38 (100.0) | 37 (100.0) | 16 (100.0) | 51 (98.1) | |
| Positive | 1 (0.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.9) | |
| MnSOD | 0.110 | |||||
| Negative | 118 (82.5) | 30 (78.9) | 34 (91.9) | 15 (93.8) | 39 (75.0) | |
| Positive | 25 (17.5) | 8 (21.1) | 3 (8.1) | 1 (6.2) | 13 (25.0) | |
| ROS status | 0.426 | |||||
| Non-activated | 136 (95.1) | 35 (92.1) | 37 (100.0) | 15 (93.8) | 49 (94.2) | |
| Activated | 7 (4.9) | 3 (7.9) | 0 (0.0) | 1 (6.2) | 3 (5.8) | |
GSTπ, Glutathione S-transferase π; TxNIP, Thioredoxin interacting protein; MnSOD, Manganese superoxide dismutase; ROS, Reactive oxygen species.