Table 3.
Ongoing studies aimed towards limiting reperfusion injury. Note: The trials that cover the cardiac surgical aspects and the maneuvers are excluded
| Drug | Sponsor | Target |
|---|---|---|
| Name of study (NCT) | Status | |
| Bendavia | Stealth Peptide Inc. Boston, USA | Mitochondrial electron transport chain |
| EMBRACE (NCT01572909) | Ongoing | |
| Cyclosporin A | Mario Negri Institute for Pharmacological Research, Italy | mPTP inhibitor |
| CYCLE (NCT01650662) | Ongoing | |
| Cyclosporin A | Hospices Civils de Lyon, France | Clincal outcomes |
| CIRCUS (NCT01502774) | Ongoing | |
| Nitric Oxide | Barts & The London NHS Trust, London, UK | Microvasculatu-re |
| NITRITE-AMI (NCT01584453) | Ongoing | |
| NIAMI (NCT01388504) | ||
| NOMI trial (NCT01398384) | ||
| Endovascular catheter cooling | Philips Helthcare, Lund University, Uppsala University | Infarct size reduction |
| CHILL-MI (NCT01379261) | Ongoing | |
| Melatonin | Herlev Hospital, Aalborg, Denmark | Antioxidant |
| (NCT01172171) | Phase II | |
| TR040303 | Trophus, European commission | mPTP antagonist |
| MITOCARE (NCT001374321) | Completed | |
| Atorvastatin | R&D Cardiologie, Netherlands | Left ventricular remodelling |
| The REPERATOR study (NCT00286312) | Completed | |
| POST AMI | University of Padua, Padua, Italy | Post conditioning |
| (NCT01004289) | Completed | |
| PRIME | Hospices Civils de Lyon, France | Delayed post conditioning |
| (NCT01483755) | Completed | |
| Post Cond No Reflow | Hospices Civils de Lyon, France | Microvascular obstruction lesions |
| (NCT01208727) | Completed | |
| Streptokinase | Istanbul University, Turkey | Microvasculatu-re |
| (NCT00627809) | Completed | |
| Endothelin | Mayo Clinic, Minnesota, USA | Microvasculature |
| (NCT00586820) | Completed | |
| Edaravone | Kumamoto University, Kumamoto, Japan | Antioxidant |
| (NCT00265239) | Completed | |
| Adenosine | Xijing Hospital, Shaanxi, China | Preconditionin-g |
| (NCT00881686) | Completed | |
| FX06, | Fibrex Medical Research & Development GmbH, | Fibrin derived peptide B beta 15-42 |
| The “F.I.R.E.” study (NCT 003269760). | Completed | |
| Adiponectin | Universiteit Antwerpen, Antwerp, Belgium | Obesrvational study |
| R2ACE (NCT01414452) | Completed | |
| Rosiglitazone | Radboud University, Nijmegen, Netherlands | Interventional study |
| (NCT00405015) | Completed | |
| Short term Statin | Radboud University, Nijmegen, Netherlands | Endothelial dysfunction |
| (NCT00987974) | Completed | |
| Black tea (Camellia sinensis) | Radboud University, Nijmegen, Netherlands | Endothelial function |
| (NCT01660516) | Completed | |
| Metformin | Radboud University, Nijmegen, Netherlands | Endothelial damage |
| MetFMD (NCT01610401) | Completed | |
| Role of Glucose and Statins | Zablocki VA Medical Center, Milwaukee, USA. | Anaesthetic preconditionin-g |
| (NCT00995670) | Completed | |
| Aspirin, Clopidogrel and Statins | Gyeongsang National University Hospital, Gyeonsangnam-do, Korea | Platelet activation, inflammation and myonecrosis |
| ACCEL-LOADING-ACS-Study (NCT01354808) | Completed | |
| Remote Post conditioning | IRCCS Policlinico S. Matteo, Italy | Post conditioning |
| RemPostCon (NCT00865722) | Completed | |
| Erythropoetin | University Hospital, Montmellier, | Infact size reduction |
| Intra-CO-EpoMI (NCT01043991) | Completed | |
| Milrinone and Esmolol | Ming-He Huang University of Texas, USA | Infarct size reduction |
| COMET-AMI (NCT 02098629) | Recruiting | |
| Remote ischemic conditioning | Arhus University Hospital Denmark, Serbia, Spain, UK | Clincal outcomes |
| CONDI2 (NCT01857414) | Recruiting | |
| Endothelial arginase inhibitor | Karolinska Institute, Stockholm, Sweden | Vasodilation by Nitric Oxide |
| (NCT02009527) | Recruiting | |
| Vit C | University of Soma La Sapienza, Rome, Italy | Antioxidant |
| TREVI (NCT01090895) | Recruiting | |
| Spironolactone | University College, London, UK | Infarct size reduction Mineralo-corticoid receptor antagonist |
| MINIMISE STEMI (NCT01882179) | Recruiting | |
| Melatonin | Herlev Hospital, Aalborg, Denmark | Infact size reduction |
| (NCT0117217) | Recruiting | |
| Glucagonlike Peptide-1 | Chinese PLA General Hsopital, Beijing, China | Myocardial salvage |
| (NCT02001363) | Recuiting | |
| DREAM | University of Leicester, Leicestershire, UK | Remote ischemic conditioning |
| (NCT01664611) | Recruiting | |
| Cooling | Medical University of Vienna, Austria | Infarct size reduction |
| STATIM (NCT01777750) | Recruiting |
Source: www.clinicaltrial.gov/CT2/show (accessed on September 10, 2014).