Table 3.
Quantitative analyses of the COMT gene val158met polymorphism on FM risk
| Variables | Na | Val/Met versus Val/Val | Met/Met versus Val/Val | Met versus Val | Val/Met + Met/Met versus Val/Val (dominant) | Met/Met versus Val/Met + Val/Val (recessive) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| OR (95% CI) | P b | OR (95% CI) | P b | OR (95% CI) | P b | OR (95% CI) | P b | OR (95% CI) | P b | ||
| Total | 8 | 1.25 (0.82-1.92) | 0.050 | 1.72 (0.61-4.87) | < 0.001 | 1.46 (0.80-2.66) | < 0.001 | 1.52 (0.80-2.90) | < 0.001 | 1.52 (0.60-3.86) | < 0.001 |
| Ethnicities | |||||||||||
| Caucasian | 5 | 1.05 (0.61-1.79) | 0.060 | 1.08 (0.48-2.44) | 0.015 | 1.03 (0.71-1.50) | 0.018 | 1.03 (0.62-1.74) | 0.048 | 1.04 (0.50-2.17) | 0.011 |
| Mixed | 3 | 1.80 (1.04-3.09) | 0.374 | 3.68 (0.51-26.48) | 0.001 | 2.57 (0.74-8.99) | < 0.001 | 2.88 (0.80-10.41) | 0.001 | 2.85 (0.55-14.73) | 0.001 |
| HWE in controls | |||||||||||
| Yes | 5 | 1.31 (0.79-1.08) | 0.170 | 1.09 (0.32-3.69) | 0.001 | 1.14 (0.67-1.93) | 0.001 | 1.29 (0.70-2.37) | 0.036 | 0.95 (0.33-2.72) | 0.001 |
| Caucasian | 3 | 1.30 (0.53-3.17) | 0.043 | 0.85 (0.22-3.34) | 0.013 | 0.98 (0.49-1.98) | 0.006 | 1.16 (0.42-3.23) | 0.011 | 0.72 (0.31-1.68) | 0.109 |
| Mixed | 2 | 1.37 (0.70-2.67) | 0.784 | 1.55 (0.08-28.29) | 0.009 | 1.45 (0.62-3.42) | 0.045 | 1.52 (0.80-2.87) | 0.484 | 1.30 (0.07-25.31) | 0.004 |
| No | 3 | 1.21 (0.51-2.86) | 0.025 | 3.41 (0.57-20.32) | < 0.001 | 2.14 (0.60-7.64) | < 0.001 | 1.98 (0.46-8.44) | < 0.001 | 3.11 (0.69-13.98) | < 0.001 |
The table given in bold indicate statistically significant values.
a
Number of comparisons.
b
P value of Q-test for heterogeneity test.
Random-effects model was used when P value for heterogeneity test, 0.10; otherwise, fix-effects model was used.