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. 2014 Dec 1;7(12):8506–8519.

Figure 5.

Figure 5

PLGF regulated the EMT-related protein expression through ERK/MAPK signaling pathway. A. Application of a specific ERK/MAPK signaling pathway inhibitor, PD98059 (10 μmol/l), or application of a specific PI3k/Akt signaling pathway inhibitor, LY294002 (20 μmol/l), or a specific JNK pathway inhibitor, SP600125 (10 μmol/l) to siha cells before treated with PLGF. PD98059 substantially abolished the decrease of E-cadherin expression by Western blot. B. Application of only PD98059 significantly decreased the migration of siha cells in a transwell assay. *P < 0.05.