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Phosphorylation-independent ephrinB1 signaling. EphrinB1 promotes cell migration through the activation of Wnt/PCP pathway by interacting with CNK1 and Dsh. In addition, ephrinB1 interacts Par-6, and sequentially releases Cdc42-GTP from intact Par polarity complex, which has a major role in stabilizing TJs. Finally, accumulation of unphosphorylated ephrinB1 in TJs causes disruption of TJs and cell adhesion.
