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. 2014 Nov 26;38(1):33–39. doi: 10.14348/molcells.2015.2163

Fig. 3.

Fig. 3.

Effect of Redβ induction and MSH2 depletion on ssOR. (A) Effect of Redβ induction on neo* correction by RO in clones Rβ1.2, Rβ1.6 and Rβ1.8 (each clone assayed once). (B) Effect of MSH2 depletion on neo* gene correction by RO in HT1080 cells with or without the induction of Redβ (n = 3). (C) The effects of Redβ induction and MSH2 depletion, separately and together, on neo* gene correction by RO in clone Rβ1.6. For all experiments: repair frequencies were calculated from frequencies of G418 colonies as described in “Materials and Methods”; parallel control experiments using CO in place of RO generated no G418-resistant colonies; means and standard deviations of ssO frequencies are shown for three independent experiments; numerical fold increases and significance (* indicates p-values of < 0.05; Student’ t-test) are shown.