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. 2014 Dec 15;172(4):1020–1033. doi: 10.1111/bph.12962

Figure 1.

Figure 1

Effects of intraplantar quisqualate injection on hot plate and von Frey's test in mice. (A) Experimental design of hot plate test. Changes in latency to shake, lick or jump after placement on hot plate (55.0 ± 0.2°C) 15 min (B) or 4 h (C) after injection of glutamatergic drugs. Eight mice were used in each group. (D) Time course of mechanical hyperalgesia induced by intraplantar injection of quisqualate. *P < 0.05 significantly different from control. (E) Effect of MPEP on quisqualate-induced mechanical allodynia. Six mice were used in each group. Data presented as mean ± SEM. *P < 0.05 significantly different from ipsilateral paw in saline group, †P < 0.05 significantly different from ipsilateral paw in quisqualate group (4 nmol per paw).