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. 2014 Dec 23;172(4):1114–1123. doi: 10.1111/bph.12985

Figure 2.

Figure 2

Damage to the endothelium (−EC) abolished hyperpolarization to ACh and 9-phenanthrol, but not to levcromakalim. Panel A, intracellular recording showing no hyperpolarization to 0.1–3.0 μM ACh or 20 μM 9-phenanthrol (9-PA), while the addition of the KATP channel activator, 5 μM levcromakalim (LVK) evoked pronounced hyperpolarization to circa EK. Panel B, concentration-response curves showing control contraction to PE is abolished in the presence of 20 μM 9-phenanthrol but re-established in endothelium-damaged arteries in the presence of 9-phenanthrol (n = 3 in each case). *, P < 0.05 vs. Control.