Table 3.
Toxicity Profiles in Patients Treated With Imatinib at 800 mg Daily
| Toxicity | No. (%) by Organ Function | |||||
|---|---|---|---|---|---|---|
| Renal (n=7) | Liver (n=31) | Normal (n=171) | ||||
| All | G3-4 | All | G3-4 | All | G3-4 | |
| Anemia | 7 (100) | 2 (29) | 29 (94) | 3 (10) | 150 (88) | 12 (7) |
| Neutropenia | 7 (100) | 4 (57) | 23 (74) | 9 (30) | 117 (68) | 52 (30) |
| Thrombocytopenia | 5 (72) | 3 (43) | 27 (87) | 9 (30) | 127 (74) | 44 (26) |
| Rash | 3 (43) | 1 (14) | 9 (29) | 3 (10) | 63 (37) | 13 (8) |
| Edema | 4 (57) | 1 (14) | 20 (65) | 0 | 94 (55) | 3 (2) |
| Nausea/vomiting | 2 (29) | 0 | 10 (32) | 0 | 44 (26) | 3 (2) |
| Diarrhea | 3 (43) | 0 | 14 (45) | 1 (3) | 51 (30) | 7 (4) |
| Liver toxicity | 3 (43) | 0 | 14 (45) | 2 (6) | 21 (12) | 5 (3) |
| Muscle cramp | 2 (29) | 0 | 12 (39) | 0 | 74 (43) | 3 (2) |
| Fatigue | 1 (14) | 0 | 5 (16) | 0 | 51 (30) | 4 (2) |
| Kidney toxicity | 2 (29) | 0 | 3 (10) | 0 | 21 (12) | 1 (1) |
| Pleural effusion | 0 | 0 | 0 | 0 | 1 (1) | 0 |
G indicates grade.