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TZDs positively affect the vasculature by decreasing the intimal medial thickness and development of atherosclerosis in the vascular smooth muscle cells. TZDs exert their protective role by inhibiting the gene expression of AT1R, TXS and TXR, involved in mechanism linked with intimal medial thickness and atherosclerosis.
TZD: Thiazolidinedione; VSMC: Vascular smooth muscle cell.
