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Paired-difference analysis of outer retina Δ1/T1ρ MRI. Layer-specific analysis of paired-difference profiles of central retinal 1/T1ρ in manganese-treated A) WT mice, B) ARR1-null mice, and C) ARR1-overexpressing mice. For Δ1/T1ρ at 64% to 72% depth, null mice but not overexpressing mice were functionally unresponsive, consistent with our hypothesis that this region reflects tet-ARR1. Data are presented using the conventions in Fig. 1.
