Table 4.

Look-up in the SYS discovery sample of adolescents of the 26 CpGs identified previously at p < 1.10^–7 in the MoBa sample of newborns.

CpG ID	Chromosome	Gene	MoBa newbornsa		SYS adolescents
			DNAm β difference (%)	p-Value	DNAm β difference (%)	p-Value
cg12803068	7	MYO1Gb	8.3	8.51 × 10–19	9.2	3.34 × 10–11b
cg22549041	15	CYP1A1b	7.2	4.52 × 10–9	4.3	9.70 × 10–5b
cg18092474	15	CYP1A1b	5.9	1.10 × 10–8	2.9	3.60 × 10–4b
cg04180046	7	MYO1Gb	5.3	8.76 × 10–20	7.2	3.90 × 10–11b
cg12477880	21	RUNX1	4.6	1.02 × 10–9	6.2	3.46 × 10–3
cg05549655	15	CYP1A1b	3.5	2.96 × 10–10	2.9	7.57 × 10–6b
cg11924019	15	CYP1A1b	3.2	2.62 × 10–8	2.8	3.35 × 10–5b
cg23067299	5	AHRRb	3.2	4.21 × 10–10	1.1	5.74 × 10–4b
cg22132788	7	MYO1Gb	2.8	1.98 × 10–18	5.5	8.41 × 10–9b
cg19089201	7	MYO1Gb	1.4	3.22 × 10–10	4.3	1.58 × 10–9b
cg03346806	8	NA	–1.5	3.08 × 10–8	–0.3	3.44 × 10–1
cg25949550	7	CNTNAP2b	–1.8	4.15 × 10–30	–2.0	3.97 × 10–9b
cg18655025	14	TTC7B	–1.8	2.07 × 10–8	–0.7	1.32 × 10–1
cg03991871	5	AHRR	–2.2	2.04 × 10–11	–2.6	7.17 × 10–2
cg21161138	5	AHRR	–2.3	1.52 × 10–11	–1.1	6.17 × 10–2
cg04598670	7	NAb	–3	1.29 × 10–11	–3.4	1.27 × 10–4b
cg10399789	1	GFI1	–3.7	4.08 × 10–13	0.6	2.09 × 10–1
cg06338710	1	GFI1	–5.8	1.34 × 10–18	0.5	5.94 × 10–1
cg09662411	1	GFI1	–6.6	2.26 × 10–20	0.0	8.37 × 10–1
cg18316974	1	GFI1	–7.1	6.43 × 10–24	0.5	8.90 × 10–1
cg05575921	5	AHRR	–7.5	2.85 × 10–39	–1.7	1.68 × 10–2
cg11715943	6	HLA-DPB2	–7.5	1.00 × 10–8	–0.7	7.10 × 10–1
cg14179389	1	GFI1b	–8.6	5.38 × 10–28	–4.7	5.13 × 10–5b
cg12876356	1	GFI1	–11.9	2.29 × 10–30	–0.5	6.63 × 10–1
cg18146737	1	GFI1	–12.3	2.42 × 10–30	0.6	8.30 × 10–1
cg09935388	1	GFI1	–13.7	1.05 × 10–38	–1.5	1.31 × 10–1
DNA methylation (DNAm) β-value differences between exposed and nonexposed individuals are shown. The SYS model A (adjusted for age, sex, batch, and blood cell fractions) is presented. aJoubert et al. (2012). bCpGs replicated in the discovery SYS sample at strict look-up–level significance (26 tests, p < 1.92 × 10–3).