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. Author manuscript; available in PMC: 2016 Feb 5.
Published in final edited form as: Eur J Pharmacol. 2014 Dec 18;748:76–82. doi: 10.1016/j.ejphar.2014.12.011

Fig. 1.

Fig. 1

Effects of different acute treatments on stretching (A) and ICSS (B) in rats treated chronically with vehicle (open bars) or morphine (filled bars). A) Abscissa: acute treatment of 1.0 mg/kg morphine or vehicle + 1.8% lactic acid or vehicle. Ordinate: number of stretches during 30-min observation period. Two-way ANOVA showed that there was a significant main effect of acute treatment [F=45.4; P<0.001], significant main effect of chronic group [F=34.1; P<0.001], and significant treatment × chronic group interaction [F=9.7; P<0.001]. B) Abscissa: acute treatment of 1.0 mg/kg morphine or vehicle + 1.8% lactic acid or vehicle. Ordinate: percent baseline number of stimulations per component. Two-way ANOVA showed that there was a significant main effect of acute treatment [F=11.8; P<0.001], no significant main effect of chronic group [F=1.2; P=0.281], and no significant treatment × chronic group interaction [F=1.6; P=0.214]. * Asterisks indicate treatments that were significantly different from vehicle + vehicle within the same group. $ Dollar signs indicate a significant antinociceptive effect of morphine relative to the Veh+LA treatment within the same group. # Number signs indicate significance between chronic vehicle and chronic morphine groups after the same acute treatment.