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. Author manuscript; available in PMC: 2016 Feb 5.
Published in final edited form as: Eur J Pharmacol. 2014 Dec 18;748:76–82. doi: 10.1016/j.ejphar.2014.12.011

Fig. 2.

Fig. 2

Effects of different acute treatments on ICSS frequency-rate curves in rats treated chronically with chronic vehicle (A) or chronic morphine (B). Abscissae: Frequency of electrical brain stimulation in Hz (log scale). Ordinates: ICSS rate expressed as percent maximum control rate (%MCR). ANOVA results were as follows: Chronic vehicle: Significant main effect of frequency [F(9,54)=184.5; P<0.001], no significant main effect of treatment [F(3,18)=3.1; P=0.055], but significant treatment × frequency interaction [F(27,126)=2.4; P<0.001]. Repeated morphine: Significant main effect of frequency [F(9,45)=142.9; P<0.001], significant main effect of treatment [F(3,15)=22.8; P<0.001], and significant treatment × frequency interaction [F(27,135)=5.8; P<0.001]. Filled points show frequencies at which a treatment produced effects significantly different from vehicle + vehicle.