Figure 4.

Primary adipocytes were cultured on standard microplates and in microfluidic devices with customized culture interfaces. 100 nM insulin treatments induced similar changes in adiponectin secretion between culture systems. Differences in secretion rate magnitudes suggest the possibility of autocrine effects of secreted agents. Additionally, on-chip stimulation with 10 μM niacin confirmed earlier findings by Judd et al. ^{11, 26}