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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Trends Pharmacol Sci. 2014 Nov 5;35(12):664–674. doi: 10.1016/j.tips.2014.10.007

Figure 5.

Figure 5

Membrane and protein targeting of SQ109 and its analogues. MenA, MenG targeting can affect respiration/electron transfer; PMF (ΔpH, Δψ) collapse leads to decreased ATP biosynthesis, reduction inPMF/ATP-powered transporters (e.g., MmpL3), increased TMM accumulation, and decreased cell wall biosynthesis. Reprinted with permission from reference [35]. Copyright 2014 American Chemical Society.